1. Intracellular calcium signaling in retinal development
2. Synaptic transmission in hippocampus
3. Pheromonal and hormonal control of behavior
4. Vestibular and visual control of eye and head movements
5. Physiological effects of odor

Clinical Laboratory Medicine


Yasuyuki Okamoto

1. Analysis of genetic mutation and polymorphism
2. Lipid and lipoprotein testing
3. Computer-assisted data analysis and diagnosis

1. Fiber orientation of collagens in the skin and its motional function
2. Application of a new method based on the collagen-fiber orientation to skingraft
3. Relationship between the orientational distribution of collagen fibers in the bone and the stress applied to the bone
4. Measurements of orientation of collagen fibers in the biological tissues
5. Effects of ultraviolet rays upon spider silk
6. Physico-chemical studies of spider silks
7. Structural-chemical study of enzyme
8. Effects of electro-magnetic waves upon biological tissues

1. Investigation of the mechanism for immunodefence
2. Immunoactivation by the protein derived fromsalivary glands
3. Hair immunology induced by activated lymphocytes
4. Activation of bioimmune system by immunoactivators in milk
5. Development of hepatocytes, pancreatic cells, alveolaepithelial cells and inner hair cells from embryonic stem cells
6. Investigation of embryonic stem cell differentiation induced by cytokines from immune cells

1. Expression of initial resistance against invading pathogens
2. Infection and immunity of intracellular parasites
3. Role of microbial proteases and superantigens forinitiation of viral infection
4. Relatedness between microbial persistence and carcinogenic process
5. Mucosal immunity to enteric infection and development of mucosal vaccines
6. Immunological deviation by nutritional and hormonal imbalance

1. Pathological studies using human surgical and autopsy specimens
   • Histologic and morphologic study
   • Clinicopathological study
   • Immunohistochemical study
   • Electron microscopic study
   • Molecular study
2. Study of desquamated and aspiration cytology
   • Morphological study
   • Immunohistochemical study
   • Molecular study

1. Therapeutic method for organ failure due to hemorrhagic shock
2. Burn reconstruction using cultured epithelial autograft
3. Electrophysiological and neuroradiological stud for CPA
4. Study for cardiac dysfuction after SAH
5. Study for cytokines m-RNA in acute respiratory failure
6. Anatomical and mechanical study for unstable pelvic fracture
7. Study for cardiopulmpnary resuscitation in prehospital patients 
8. Study for pulmonary capillary permeability in septic shock
9. Blood coagulation in emergency medical field
10. Molecular mechanism for ending of inflammation

1. Establishment of theory regarding stress control of pain and neural transmission
2. Development of therapy for pain, especially intractable pain
3. Basic researches for neural transmission, especially myogenic motor evoked potentials
4. Establishment of methodology regarding clinicalapplications for myogenic motor evoked potentials
5. Basic researches for therapeutic hypothermia
6. Establishment of methodology regarding clinical applications for therapeutic hypothermia
7. Basic researches regarding new methods of assessmentfor cardiac function
8. Clinical applications for new methods of assessment for cardiac function

1. Explore the role of oxidative stress in the progressionof atherosclerosis
2. Development of new drugs for atherosclerosis from natural food nutrients
3. Mechanisms of vasoactive substance-induced vascular remodeling in hypertension and atherosclerosis
4. Investigation into the molecular mechanisms and pharmacological intervention for angiogenesis
5. Analysis of intracellular signal transduction of insulin resistance in vascular smooth muscle cells
6. Explore the role of oxidative stress in the progression of neurodegenerative diseases
7. Study for the dynamics of intracellular calcium in contraction and relaxation of cardiomyocytes and vascular smooth muscle cells
8. Pharmacological and physiological analysis of the mechanisms of automaticity in sinus node cells
9. Regenerative medicine for the induction of differentiated cardiomyocytes from embryonic stem cells
10. Investigation into the mechanisms of intracellular signal transduction in neural type nicotinic acetylcholine receptor 

1. Research on interaction between host and microorganism in infectious diseases
2. Research on host defense and its control in respiratory tract infection
3. Research on biological activity of antimicrobial agents against resistant bacteria
4. Research on pathogenesis and treatment of HIV infection
5. Research on early diagnosis and multidisciplinary treatment of deep-seated fungal diseases
6. Research on molecular epidemiology of drug resistant bacteria
7. Research on appropriate use of antimicrobial agents

1. Molecular mechanism of odor perception
2. Molecular mechanism for organizing the olfactory sensory map in the brain
3. Regulatory mechanism of single gene expression in the odorant receptor gene family
4. Mechanism for the axonal projection of olfactory sensory neurons
5. Strategy for the gene expression specific to olfactory sensory neurons by the Cre-loxP system
6. Differentiation of neural stem cells in the olfactory system
7. Regenerative medicine for central and peripheral neurons

1. Pathophysiology and treatment of liver cirrhosis (Ascites, Esophagogastric Varices, Hepatorenal syndrome)
2. Endotoxin,blood coagulation and organ injury
3. Diagnosis and treatment of chronic hepatitis
4. Pathophysiology and treatment of hepatocellular carcinoma  (Angiogenesis, Drug resistence)
5. Mechanism and Pathophysiology of liver fibrosis
6. Liver transporter proteins in cholestatic liver disease
7. Pathophysiology of gastroduodenal mucosal lesions
8. Life style related gastrointestinal function and liver 　disturbance
9. Hepatic regeneration
10. Genetic analysis of colon cancer

1. Pathogenesis and mechanisms of airway remodeling / pulmonary vascular remodeling
2. Regenerative medicine in epithelial and endothelial cells of the lung in patients with pulmonary emphysema
3. Analyses on genetic and nutritional factors and development of therapeutic strategy for patients with COPD
4. Pathogenesis and the therapeutic strategy for refractory pulmonary hypertension
5. Analyses of the pathogenesis and mechanisms of chronic thromboembolic pulmonary hypertension
6. Molecular mechanisms of the hypoxia-reoxygenation injury in patients with sleep disordered breathing
7. Molecular mechanisms of the role of chemokines and dendritic cells on the infectious pulmonary diseases
8. The role of air-pollution on the molecular mechanisms of airway remodeling of bronchial asthma
9. The role of chemokines and dendritic cells in theautoimmune and allergic diseases
10. Molecular mechanisms of hypoxic stress during sleep in patients with metabolic syndrome
11. Molecular mechanisms of growth and progression in lung cancer
12. Construction of the “tailor-made therapy” for lung cancer
13. Development of the new therapeutic strategy with dendritic cells
14. Regulation of immune response after hematopoietic stem cell trasplantation
15. Functionnal analysis of actication antigen CD69
16. The role of trace elements on hematopoietic diseases

1. Framing of a guideline for therapy of chronic heart failure
2. Prevention of cardiovascular diseases in accordance with genetic risk factors
3. Investigation of molecular mechanism for heart failure
4. Development of therapeutic angiogenesis in ischemic limband cardiomyopathy
5. Development of a novel thrombolytic therapy in combination with ultrasound for acute myocardial infarction
6. Molecular biological approach for prevention of coronary artery stenosis
7. Investigation of the molecular mechanism for heart failure-related ventricular arrhythmia
8. Molecular biological approach for inhibition of expansion of infarct size
9. Investigation of the molecular mechanism for cardiovascularcomplication in diabetes mellitus
10. Investigation of the molecular mechanism of vascular complications in renal failure
11. Investigation of the molecular mechanism for renal interstitial fibrosis

1. Translational Research for Gynecological Cancers by Anti-Metastatic Compounds
2. Ant-Metastasis Gene Therapy for Patients with Ovarian Cancer
3. Drug Delivery System of Anti-Metastatic Compound by Computer Analysis
4. Mechanism of Metastasis of Gynecological Cancers
5. Gene Profiling of Chemo-Resistance in Gynecological Cancer
6. Gene Profiling of Development of Endometriosis-Associated Ovarian Cancer
7. Gene Profiling of Familiar Endometrial Cancer
8. Establishment of Criteria for Adenoma Malignumof the Uterine Cervix
9. Prediction and Screening for Early-stage Ovarian Cancer
10. Epidemiology of Venous Thromboembolism in Pregnancy and Puerperium
11. Prediction of Premature Delivery using Biomarkers
12. Establishment of Standard for Prediction of Premature Delivery
13. Pathophysiology of Twin to Twin Transfusion Syndrome
14. Establishment of Criteria for Pulmonary Embolism by Surface Plasmon Resonance
15. A Cohort Study for Pregnancy, Lactation and Medicine
16. A Cohort Study for Cytomegarovirus Infection in Pregnancy
17. Study for Pathophysiology of Preeclampsia and Fetal Growth and Development in Preeclampsia Patients
18. Development of a novel feto-maternal monitoring system

1. Mechanism of pseudoaccommodation
2. Studies of E.R.G., V.E.P
3. Refractive Surgery
4. Studies of artificial vitreous body
5. Studies of corneal regeneration
6. Studies of corneal epithelium and cytokine
7. Studies of retinal regeneration
8. Development of accommodative intraocular lens
9. Mechanism of myopic generation
10. Studies of phase transition
11. Studies of dynamic laser scattering of ocular tissue
12. Studies of ocular aberration

1. Immunological analysis of atopic dermatitis
2. A role for Toll-like receptor in allergic contact dermatitis
3. Pathogenic role for viral infection in allergic skin diseases
4. Studies on clinical, serological, and immunogenetic features in autoimmune bullous diseases
5. Mechanism in carcinogenesis of EB virus-associated malignant lymphoma
6. Mechanism in metastasis of malignant melanoma
7. Studies on skin damage by ultraviolet light
8. Studies on skin and hair regeneration
9. Molecular-biological research on pathogenic mechanismof hypertrophic scar
10. Pathological analysis of skin tumor to find new diagnostic procedure