ホーム > 研究・産学官連携 > 先端医学研究機構 > 循環器システム医科学 > Publication

ここから本文です。

更新日:2015年3月1日

Publication

Osamu NAKAGAWA, Selected Publication

Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y. Tmem100, an ALK1 signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc. Nat. Acad. Sci. USA 109(30): 12064-12069, 2012.

Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am. J. Physiol. 294(3): F542-553, 2008.

Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc. Nat. Acad. Sci. USA 104(19): 7975-7980, 2007.

King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O. Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem. Biophys. Res. Commun. 345(1): 446-452, 2006.

Murakami M, Nakagawa M, Olson EN, Nakagawa O. A WW domain protein TAZ is a critical co-activator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Nat. Acad. Sci. USA 102(50): 18034-18039, 2005.

Nakagawa O, Arnold M, Nakagawa M, Hamada H, Shelton JM, Kusano H, Harris TM, Childs G, Campbell KP, Richardson JA, Nishino I, Olson EN. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 19(17): 2066-2077, 2005.

Phan D, Rasmussen TL, Nakagawa O, McAnally J, Gottlieb PD, Tucker PW, Richardson JA, Bassel-Duby R, Olson EN. Bop, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the anterior heart field. Development 132(11): 2669-2678, 2005.

Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JA, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J. Biol. Chem. 279(52): 54937-54943, 2004.

Gottlieb PD, Pierce SA, Sims RJ III, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nature Genet. 31(1): 25-32, 2002.

Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricular formation. Dev. Biol. 239(2): 190-203, 2001.

Liu Z-P*, Nakagawa O*, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN (* equal contribution). CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev. Biol. 234(2): 497-509, 2001.

Nakagawa M, Tanaka I, Mukoyama M, Suga S, Ogawa Y, Tamura N, Ishibashi R, Goto M, Nakagawa O, Sugawara A, Nakao K. Monoclonal antibody against brain natriuretic peptide (BNP) and characterization of BNP-transgenic mice. J. Hypertens. 19(3): 475-483, 2001.

Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of bHLH proteins act as transcriptional repressors downstream of Notch signaling. Proc. Nat. Acad. Sci. USA 97(25): 13655-13660, 2000.

Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D. HRT1, HRT2, HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments. Dev. Biol. 216(1): 72-84, 1999.

Harada E, Nakagawa O, Yoshimura M, Harada M, Nakagawa M, Mizuno Y, Shimasaki Y, Nakayama M, Yasue H, Kuwahara K, Saito Y, Nakao K. Effect of interleukin-1beta on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture. J. Mol. Cell. Cardiol. 31(11): 1997-2006, 1999.

Harada M, Itoh H, Nakagawa O, Ogawa Y, Miyamoto Y, Kuwahara K, Ogawa E, Igaki T, Yamashita J, Masuda I, Yoshimasa T, Tanaka I, Saito Y, Nakao K. Significance of ventricular myocytes and nonmyocytes interation during cardiocyte hypertrophy. -Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes.- Circulation 96(10): 3737-3744, 1997.

Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS lett. 392(2): 189-193, 1996.

Hama N, Itoh H, Shirakami G, Nakagawa O, Suga S, Ogawa Y, Masuda I, Nakanishi K, Yoshimasa T, Hashimoto Y, Yamaguchi M, Hori R, Yasue H, Nakao K. Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. Circulation 92(6): 1558-1564, 1995.

Nakagawa O, Ogawa Y, Itoh H, Suga S, Komatsu Y, Kishimoto I, Nishino K, Yoshimasa T, Nakao K. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. -Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload-. J. Clin. Invest. 96(3): 1280-1287, 1995.

Nakagawa O, Tanaka I, Usui T, Harada M, Sasaki Y, Itoh H, Yoshimasa T, Namba T, Narumiya S, Nakao K. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Circulation 90(4): 1643-1647, 1994.

Masahide SAKABE, Selected Publication

Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y. Tmem100, an ALK1 signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc. Nat. Acad. Sci. USA 109(30): 12064-12069, 2012.

Sakabe M, Kokubo H, Nakajima Y, Saga Y. Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-TGFbeta2 pathway. Development 139(2): 385-395, 2012.

Yanagawa N, Sakabe M, Sakata H, Yamagishi T, Nakajima Y. Nodal signal is required for morphogenetic movements of epiblast layer in the pre-streak chick blastoderm. Dev. Growth. Differ. 53(3): 366-377, 2011.

Nakajima Y, Sakabe M, Matsui H, Sakata H, Yanagawa N, Yamagishi T. Heart development before beating. Anat. Sci. Int. 84(3): 67-76, 2009.

Sakabe M, Sakata H, Matsui H, Ikeda K, Yamagishi T, Nakajima Y. ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation. Anat. Rec. 291(7): 845–857, 2008.

Matsui H*, Sakabe M*, Sakata H, Yanagawa N, Ikeda K, Yamagishi T, Nakajima Y. (* equal contribution). Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and FGF8. Dev. Growth. Differ. 50(3): 143-157, 2008.

Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N. Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am. J. Pathol. 170(3): 967-980, 2007

Sakata H, Sakabe M, Matsui H, Kawada N, Nakatani K, Ikeda K, Yamagishi T, Nakajima Y. Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm. Dev. Dyn. 236(2): 461-472, 2007.

Sakabe M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi T, Nakajima Y. Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation. Dev. Dyn. 235(1): 94-104, 2006.

Sakabe M, Matsui H, Sakata H, Ando K, Yamagishi T, Nakajima Y. Understanding heart development and congenital heart defects through developmental biology: a segmental approach. Congenit. Anom. 45(4): 107-118, 2005.

 

Laboratory for Cardiovascular System Research
Nara Medical University Advanced Medical Research Center
2013