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2005

J. A. Plock, C. Contaldo, H. Sakai, E. Tsuchida, M. Leunig, A. Banic, M.D. Menger, D. Erni. Is the Hb in Hb-vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin? Am. J. Physiol. Heart Circ. Physiol 289, H2624-H2631 (2005, Dec).

H. Sakai, P. Cabrales, A.G. Tsai, M. Intaglietta, E. Tsuchida. Oxygen Release from low and normal P50 Hb-vesicles in Transiently Occluded Arterioles of the Hamster Window Model. Am. J. Physiol. Heart Circ. Physiol. 288, H2897-H2903 (2005, June).

C. Contaldo, J. Plock, H. Sakai, S. Takeoka, E. Tsuchida, M. Leuing, A. Banic, and D. Erni. New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue. Crit. Care Med. 33, 806-812 (2005, April).

P. Cabrales, H. Sakai, A.G. Tsai, S. Takeoka, E. Tsuchida, M. Intaglietta. Oxygen transport by low and normal P50 Hb-vesicles in extreme hemodilution. Am. J. Physiol. Heart Circ. Physiol 288: H1885-H1892 (2005, April).

E. Tsuchida, H. Sakai, T. Komatsu, K. Kobayashi. Clinical application of artificial oxygen carriers. In: Advanced Medical Treatment 37, Artificial organs and regenerative medicine. Chapter 16-4, pp 279-286, 2005, Terada International Office and Advanced Medical Technology Laboratory. (in Japanese). 土田英俊、酒井宏水、小松晃之、小林紘一、酸素輸液(人工赤血球)の臨床応用。先端医療シリーズ37「人工臓器・再生医療の最先端」第16-4. pp. 279-286, 2005. 寺田国際事務所 / 先端医療技術研究所 (11)

H. Sakai, E. Tsuchida. Artificial red cells homogeneously distributed in microciruclation and their fate. Bioscience and Industry 63, 571-572 (2005). (in Japanese). 酒井宏水, 土田英俊. 目でみるバイオ「微小血管内を均一に流れる人工赤血球と その運命」. バイオサイエンスとインダストリー 63, 571-572 (2005, 9).

H. Sakai and E. Tsuchida. Comments on a report "Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics." Artif. Blood 13, 122-127 (2005) (in Japanese). 酒井宏水、土田英俊、海外文献紹介"P50値の低いヘモグロビンによる酸素ターゲッティング: 酸素治療の新しい原理". 人工血液 13, 122-127 (2005).

H. Sakai, K. Sou, S. Takeoka, K. Kobayashi, E. Tsuchida. Artificial Red Cells. In: Biomedical Materials and Functional Membrane. Chapter 5, pp 107-118, CMC Publisher, Tokyo (in Japanese). 酒井宏水、宗慶太郎、武岡真司、小林紘一、土田英俊. 人工赤血球. 「医療用マテリアルと機能膜」5章、pp 107-118, シーエムシー出版, 2005. 5.31

E. Tsuchida, H. Sakai, T. Komatsu, S. Takeoka, Y. Huang, K. Sou, A. Nakagawa, Y. Teramura, and K. Kobayashi. Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nano-Molecular Sciences. Polymers Adv. Technol. 16, 73-83 (2005).

H. Sakai, K. Sou, S. Takeoka, K. Kobayashi, E. Tsuchida. “Hemoglobin-vesicles (HbV) as Artificial Oxygen Carriers”.In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12, pp. 135-168, Eds. by K. Kobayashi, E. Tsuchida, and H. Horinouchi. Springer-Verlag (2005).

K. Kobayashi, H. Horinouchi, M. Watanabe, Y. Izumi, Y. Teramura, A. Nakagawa, Y. Huang, K. Sou, H. Sakai, T. Komatsu, S. Takeoka, E. Tsuchida. “Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes”. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12, pp. 1-21, Eds. by K. Kobayashi, E. Tsuchida, and H. Horinouchi. Springer-Verlag (2005).


2004

H. Sakai, Y. Masada, H. Horinouchi, E. Ikeda, K Sou S. Takeoka, M. Suematsu, M. Takaori, K. Kobayashi, E. Tsuchida. Physiologic capacity of reticuloendothelial system for degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days. J. Pharmacol. Exp. Therap. 311, 874-884 (2004 Dec.)

H. Sakai, Y. Masada, H. Onuma, S. Takeoka, E. Tsuchida. Reduction of methemoglobin via electron transfer from photoreduced flavin: restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles. Bioconjugate Chem. 15, 1037-1045 (2004, Sept.).

A. Yoshizu, Y. Izumi, S. Park, H. Sakai, S. Takeoka, H. Horinouchi, E. Ikeda, E. Tsuchida, K. Kobayashi. Hemorrhagic shock resuscitation with an artificial oxygen carrier Hemoglobin Vesicle (HbV) maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor alpha (TNFa). ASAIO J. 50, 458-463 (2004, Sept.).

H. Sakai, H. Horinouchi, Y. Masada, S. Takeoka, M. Takaori, K. Kobayashi, E. Tsuchida. Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model. Biomaterials 25, 4317-4325 (2004, Aug.).

H. Sakai, Y. Masada, H. Horinouchi, M. Yamamoto, E. Ikeda, S. Takeoka, K. Kobayashi, E. Tsuchida. Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats. Crit. Care Med. 32, 539-545 (2004).

H. Sakai, S. Hisamoto, I. Fukutomi, K. Sou, S. Takeoka, and E. Tsuchida. Detection of Lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gell clotting analysis and pretreatment of surfactant. J. Pharm. Sci. 93, 310-321 (2004).

E. Tsuchida, S. Takeoka, T. Komatsu, H. Sakai. “Artificial Red Cells” In: Basics and Application of Surface Science (Ed. by Jpn Soc. Surface Science), Chapter 5-12, pp. 1333-1336, 2004, NTS Publisher, Tokyo. (in Japanese) 土田英俊、武岡真司、小松晃之、酒井宏水人工赤血球「新訂版・表面科学の基礎と応用」第5章第12 pp. 1333-1336、編者: 日本表面科学会、エヌ・ティー・エス社 (2004) (2004. 6. 22).

A.G. Tsai, H. Sakai, R. Wettstein, H. Kerger, M. Intaglietta. An effective blood substitutes that targets oxygen delivery, increases plasma viscosity, and has high oxygen affinity. Transfusion Alternatives in Transfusion Medicine 5, 507-513 (2004).

Y. Goto, T. Kondo, T. Ide, H. Yasueda, N. Kuramoto, K. Yamamoto. Cry j 1 isoforms derived from Cryptomeria japonica trees have different binding properties to monoclonal antibodies. Clin. Exp. Allergy 34, 1754-1761 (2004).

K. Yamamoto, A. Nakayama, Y. Yamamoto, S. Tabata. Val216 decides the substrate specificity of a-glucosidase in Saccharomyces cerevisiae, Eur. J. Biochem. 271, 3414-3420 (2004).

S. Osaki, K. Yamamoto, A. Kajiwara, M. Murata. Evaluation of the resistance of spider silk to ultraviolet irradiation. Polymer J. 36, 623-627 (2004)..


2003

S. Hisamoto, H. Sakai, I. Fukutomi, K. Sou, S. Takeoka, E. Tsuchida. Detection of lipopolysaccharide contaminating hemoglobin-vesicles as artificial oxygen carriers. Artif. Blood 11, 173-178 (2003). 久本秀治、酒井宏水、福富一平、宗慶太郎、武岡真司、土田英俊. 酸素輸液ヘモグロビン小胞体に混在するリポポリサッカライドの定量法. 人工血液 11, 173-178 (2003).

Y. Teramura, H. Kanazawa, H. Sakai, S. Takeoka, E. Tsuchida. Prolonged oxygen -carrying ability of Hb vesicles by coencapsulation of catalase in vivo. Bioconjugate Chem. 14: 1171-1176 (2003)

H. Sakai, Y. Suzuki, M. Kinoshita, S. Takeoka, N. Maeda, E. Tsuchida. O2 Release from Hb vesicles evaluated using an artificial, narrow O2-permeable tube: comparison with RBCs and acellular Hbs. Am. J. Physiol. Heart Circ. Physiol. 285, H2543-H2551 (2003).

C. Contaldo, S. Schramm, R. Wettstein, H. Sakai, S.Takeoka, E. Tsuchida, M. Leunig, A. Banic, D. Erni. Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity. Am. J. Physiol. Heart Circ. Physiol. 285: H1140-H1147 (2003).

D. Erni, R. Wettstein, S. Schramm, H. Sakai, S. Takeoka, E. Tsuchida, M. Leunig, A. Banic. Normovolemic hemodilution with hemoglobin-vesicle solution attenuates hypoxia in ischemic hamster flap tissue. Am. J. Physiol. Heart Circ. Physiol. 284, H1702-H1709 (2003)

H. Sakai, K. Tomiyama, Y. Masada, S. Takeoka, H. Horinouchi, K. Kobayashi, E. Tsuchida. Pretreatment of serum containing Hb-vesicels (oxygen carriers) to prevent their interference in laboratory tests. Clin. Chem. Lab. Med. 41, 222-231 (2003).

T. Shirasawa, M. Izumizaki, Y.I. Suzuki, A. Ishihara, T. Shimizu, M. Tamaki, F. Huang, K.I. Koizumi, M. Iwase, H. Sakai, E. Tsuchida, K. Ueshima, H. Inoue, H. Koseki, T. Senda, T. Kuriyama, I. Homma. Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity. J. Biol. Chem. 278, 5035-5043 (2003).

E. Tsuchida, T. Komatsu, Y. Matsukawa, A. Nakagawa, H. Sakai, K. Kobayashi, M. Suematsu. Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging. J. Biomed. Mater. Res. 64A, 257-261 (2003).

H. Sakai and E. Tsuchida. Comments on a report "Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute." Artif. Blood  11, 211-214 (2003) (in Japanese).  酒井宏水, 土田英俊. 海外文献紹介 "赤血球代替物を用いる蘇生法による外傷後過剰炎症反応の変化." 人工血液 11, 211-214 (2003).

E. Tsuchida, K. Sou, H. Sakai, T. Komatsu, S. Takeoka, H. Horinouchi, M. Suematsu, K. Kobayashi. Safety of artificial oxygen carrier (synthetic erythrocytes) and the ability to supply oxygen to tissues] Masui. 52 Suppl, S55-66 (2003). (in Japanese) 土田英俊、宗慶太郎、酒井宏水、小松晃之、武岡真司、堀之内宏久、末松誠、小林紘一“酸素輸液(人工赤血球)の安全度と体組織への酸素供給”麻酔 53(増刊号) S55-S66 (2003)

E. Tsuchida, H. Sakai, S. Takeoka, K. Sou, K. Kobayashi. Oxygen Infusion(aritificial red cells). J. Clin. Exp. Med. (Igaku no Ayumi) 205, 558-566 (2003) (in Japanese) 土田英俊、酒井宏水、武岡真司、宗慶太郎、小林紘一酸素輸液(人工赤血球)” 医学のあゆみ 205, 558-566 (2003)

F. Huang, M. Tamaki, T. Shimizu, M. Izumizaki, I. Homma, A. Ishihara, H. Sakai, E. Tsuchida, H. Inoue, K. Ueshima, and T. Shirasawa. The treatment of respiratory failure -through research of the mutant haemoglobins- Kokyu (Respiration) 22,101-110 (2003). 菲、玉置正勝、清水孝彦、泉崎雅彦、本間生夫、石原昭彦、酒井宏水、土田英俊、井上洋西、上嶋健治、白澤卓二呼吸不全の遺伝子治療-変異ヘモグロビンの研究を通じて-” 呼吸 22, 101-110 (2003)

Y. Goto, T. Kondo, N. Kuramoto, T. Ide, K. Yamamoto, K. Inaoka, H. Yasueda. Mapping the gene encoding Cry j 1: a major Cryptomeria japonica pollen allergen, Silvae Genetica 52, 97-99 (2003).

A. Nakayama, K. Yamamoto, S. Tabata. The amino acid residues involved in catalysis of the yeast glycogen debranching enzyme. J. Appl. Glycosci. 50, 299 (2003).


2002

E. Tsuchida, T. Komatsu, T. Yanagimoto, H. Sakai. Preservation stability and in vivo administration of albumin-heme hybrid solution as an entirely synthetic O2-carrier. Polymers Adv. Technol. 13, 845-850 (2002).

H. Sakai, S. Takeoka, R. Wettstein, A.G. Tsai, M. Intaglietta, E. Tsuchida. Systemic and Microvascular responses to the hemorrhagic shock and resuscitation with Hb-vesicles. Am. J. Physiol. Heart Circ. Physiol. 283, H1191-H1199 (2002).

H. Sakai, K. Tomiyama, Y. Masada, S. Takeoka, H. Horinouchi, K. Kobayashi, E. Tsuchida. Clinical chemistry of blood serum containing hemoglobin-vesicles as O2 carriers. Artif. Blood 10, 47-53 (2002)  酒井宏水、富山賢一、政田陽平、武岡真司、堀之内宏久、小林紘一、土田英俊.  酸素輸液(ヘモグロビン小胞体)を含有する血液の生化学検査. 人工血液 10, 47-53 (2002).

Y. Suzuki, T. Shimizu, H. Sakai, M. Tamaki, K. Koizumi, T. Kuritama, E. Tsuchida, H. Koseki, T. Shirasawa. Model mice for Presbyterian hemoglobinopathy (Asnβ108Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb. Biochem. Biophys. Res. Commun. 295, 869-876 (2002).

Y. Naito, I. Fukutomi, Y. Masada, H. Sakai, S. Takeoka, E. Tsuchida, H. Abe, J. Hirayama, K. Ikebuchi, and H. Ikeda. Virus removal from hemoglobin solution using Planova membrane. J. Artif. Organs 5, 141-145 (2002).

I. Fukutomi, H. Sakai, S. Takeoka, E. Tsuchida, and K. Sakai. Carbonylation of oxyhemoglobin solution (HbO2 HbCO) using a membrane oxygenator. J. Artif. Organs 5, 102-107 (2002).

H. Sakai, T. Sato, Y. Maekawa, and E. Tsuchida. Capillary blood flow during severe hemodilution observed by a noninvasive transcutaneous technique using flash epi-illumination. Microvasc. Res. 64, 120-126 (2002).

H. Sakai, Y. Masada, S. Takeoka, and E. Tsuchida. Characteristics of bovine hemoglobin as a the potential source of hemoglobin-vesicles for an artificial oxygen carrier. J. Biochem. 131, 611 - 617 (2002).

Y. Huang, S. Takeoka, H. Sakai, H. Abe, J. Hirayama, K. Ikebuchi, H. Ikeda, and E. Tsuchida. Complete deoxygenation from a hemoglobin solution by an electrochemical method and heat treatment for virus inactivation. Biotechnol. Progress 18, 101-107 (2002).

E. Tsuchida, H. Sakai. “Oxygen Infusion (Hemoglobin vesicles)” in “Encyclopedia of Particle Technology” Vo. 2, Chapt. 12-1, pp.665-669, Fuji Technosystem Publisher (2002). 土田英俊、酒井宏水 "酸素輸液(ヘモグロビン小胞体)" 「微粒子工学体系」第二巻応用技術、第121, pp. 665-669, フジ・テクノシステム,  (2002).

T. Nakaishi, K. Iio, K. Yamamoto, I. Urabe, T. Yomo. Kinetic properties of Qb replicase, an RNA dependent RNA polymerase. J. Biosci. Bioeng. 93, 322-327 (2002).

山本、花粉アレルゲンの遺伝子解析、生物工学 80, 148-152, (2002).

中山章文、山本惠三、稲岡心、田端司郎、酵母Glycogen debranching enzymeの2つの酵素作用とその触媒残基について J. Appl. Glycosci. 49, 181-190 (2002).


2001

T. Ito, M. Fujihara, H. Abe, M. Yamaguchi, S. Wakamoto, S. Takeoka, H. Sakai, E. Tsuchida, H. Ikeda, and K. Ikebuchi. Effects of poly (ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucyl-phenylalanine induced respoonses of polymorphonuclear neutrophils in vitro. Artif. Cells Blood Substitutes Immobilization Biotechnol. 29, 427-438 (2001).

H. Abe, K. Ikebuchi, J. Hirayama, M. Fujihara, S. Takeoka, H. Sakai, E. Tsuchida, and H. Ikeda. Virus inactivation in hemoglobin solution by heat treatment. Artif. Cells Blood Substitutes Immobilization Biotechnol. 29, 381-388 (2001).

H. Sakai, H. Horinouchi, K. Tomiyama, E. Ikeda, S. Takeoka, K. Kobayashi, and E. Tsuchida. Hemoglobin-vesicles as oxygen carriers: Influence on phagocytic activity and histopathological changes in reticuloendothelial system. Am. J. Pathol. 159, 1079-1088 (Sept. 2001).

S. Wakamoto, M. Fujiwara, H. Abe, H. Sakai, S. Takeoka, E. Tsuchida, H. Ikeda, and K. Ikebuchi. “Effects of PEG-modified hemoglobin vesicles on agonist induced platelet aggregation and RANTES release in vitro. Artif. Cells Blood Substitues Immobilization Biotechnol. 29, 191-201 (2001).

E. Tsuchida, T. Komatsu, and H. Sakai. Function and evaluation of oxygen infusions (artificial red cells). Blood Immunity Cancer (BIC Forum) 6, 12-18 (2001) (in Japanese)   土田英俊、小松晃之、酒井宏水. "酸素輸液(人工赤血球)の設計原理とその具体的構造." 季刊誌「血液・免疫・腫瘍」BIC Forum 6, 12-18 (2001).

A. Nakayama, K. Yamamoto, S. Tabata. The role of Asp-224 in conserved region I of yeast glycogen debranching enzyme. Appl. Biol. Sci 7, 37-47 (2001).

A. Nakayama, K. Yamamoto, S. Tabata. Identification of the catalytic residues of bifunctional glycogen debranching enzyme. J. Biol. Chem. 276, 28824-28828 (2001).

K. Yamamoto, G. Kurisu, M. Kusunoki, S. Tabata, I. Urabe, S. Osaki. Crystal structure of glucose dehydrogenase from Bacillus megaterium IWG3 at 1.7 Å resolution. J. Biochem. 129, 303-312 (2001).


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