■ 原 著
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima KI, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y.
Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.
Kidney Int. 2012 Jan 4. doi: 10.1038/ki.2011.423. [Epub ahead of print]
■ 国際学会発表
■ 受 賞
|
2011年度/研究業績 |
■ 原 著
Nishida T, Nakajima T, Kaitani K, Takitsume A, Soeda T, Okayama S, Somekawa S, Takeda Y, Ishigami KI, Kawata H, Kawakami R, Horii M, Uemura S, Saito Y.
Non-contact mapping system accurately localizes right-sided accessory pathways in type B Wolff-Parkinson-White syndrome.
Europace. 2011 Dec 1. [Epub ahead of print]
Takami T, Saito Y.
Effects of smoking cessation on central blood pressure and arterial stiffness.
Vasc Health Risk Manag, 7:633-638, 2011
Kubo A, Stull R, Takeuchi M, Bonham K, Gouon-Evans V, Sho M, Iwano M, Saito Y, Keller G, Snodgrass R
Pdx1 and Ngn3 Overexpression Enhances Pancreatic Differentiation of Mouse ES Cell-Derived Endoderm Population.
PLoS One. 6(9):e24058, 2011
Iwano M, Yamaguchi Y,Iwamoto T, Nakatani K, Matsui M, Kubo A, Akai Y, Mori T, Saito Y
Urinary FSP1 Is a Biomarker of Crescentic GN.
J Am Soc Nephrol. 2011 Nov 17. [Epub ahead of print]
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyere F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M
Macrophage Skewing by PHD2 Haplodeficiency Prevents Ischemia by Inducing Arteriogenesis.
Nature. 479(7371):122-6, 2011
Uemura S, Ishigami K, Soeda T, Okayama S, Sung JH, Nakagawa H, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y
Thin-Cap Fibroatheroma and Microchannel Findings in Optical Coherence Tomography Correlate with Subsequent Progression of Coronary Atheromatous Plaques.
Eur Heart J. 33(1):78-85, 2012 Epub 2011 Aug 10.
Soeda T, Uemura S, Okayama S, Kawakami R, Sugawara Y, Nakagawa H, Matsumoto T, Sung JH, Nishida T, Senoo A, Somekawa S, Takeda Y, Ishigami K, Kawata H, Horii M, Saito Y
Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. -Evaluation using dual-source computed tomography.-.
Circ J. 75(11):2621-7, 2011
Maisel AS, Nakao K, Ponikowski P, Peacock WF, Yoshimura M, Suzuki T, Tsutamoto T, Filippatos GS, Saito Y, Seino Y, Minamino N, Hirata Y, Mukoyama M, Nishikimi T, Nagai R
Japanese-Western consensus meeting on biomarkers.
Int Heart J. 52(5):253-65, 2011
Takami T, Saito Y
Effects of Azelnidipine plus OlmesaRTAn versus amlodipine plus olmesartan on central blood pressure and left ventricular mass index:the AORTA study.
Vascular Health and Risk Management. 7:383-390, 2011
Okayama S, Seno A, Soeda T, Takami Y, Kawakami R, Somekawa S, Ishigami K, Takeda Y, Kawata H, Horii M, Uemura S, Saito Y
Optimization of energy level for coronary angiography with dual-energy and dual-source computed tomography.
Int J Cardiovasc Imaging. 2011 Jun 3. [Epub ahead of print]
Saito Y, Kishimoto I, Nakao K
Roles of guanylyl cyclase-A signaling in the cardiovascular system.
Can J Physiol Pharmacol. 89(8):551-6, 2011
Okada S, Morimoto T, Ogawa H, Kanauchi M, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sakuma M, Saito Y;for the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Investigators.
Differential Effect of Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Diabetic Management: A Subanalysis of the JPAD Trial.
Diabetes Care. 34(6):1277-1283, 2011
Okayama S, Soeda T, Seno A, Watanabe M, Nakajima T, Uemura S, Saito Y
Rare Concurrence of Apical Hypertrophic Cardiomyopathy and Effusive Constrictive Pericarditis.
Open Cardiovasc Med J. 5:99-102, 2011
Okayama S, Seno A, Soeda T, Takami Y, Horii M, Uemura S, Saito Y
Myocardial hypoperfusion detected by cardiac computed tomography in an adult patient with heart failure after classic repair for corrected transposition of the great arteries.
Acta Cardiologica. 66(4):535-6, 2011
Sakan H, Okayama S, Uemura S, Somekawa S, Ishigami K, Takeda Y, Kawata H, Horii M, Fujimoto S, Saito Y
Atrial right-to-left shunt without pulmonary hypertension in a patient with biventricular non-compaction cardiomyopathy accompanied by ventricular and atrial septal defects.
Intern Med. 50(16):1747-51, 2011
Okayama S, Ayako S, Somekawa S, Uemura S, Kubota Y, Saito Y
Feasibility of dual gradient-echo in-phase and opposed-phase magnetic resonance imaging for the evaluation of epicardial fat.
Acta Radiol. 52(7):723-9, 2011
Saito Y, Morimoto T, Ogawa H, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sugiyama S, Okada S, Akai Y
Low-dose Aspirin Therapy in Patients With Type 2 Diabetes Mellitus and Reduced Glomerular Filtration Rate: Subanalysis from the JPAD Trial.
Diabetes Care. 34(2):280-285, 2011
Okayama S, Uemura S, Soeda T, Onoue K, Somekawa S, Ishigami K, Watanabe M, Nakajima T, Fujimoto S, Saito Y
Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction.
Int J Cardiol. 146(1):73-9, 2011
Soeda T, Okayama S, Seno A, Kawakami R, Somekawa S, Takeda Y, Uemura S, Saito Y.
Contrast-enhanced computed tomographic and echocardiographic detection of intra-aortic free floating thrombus causing acute myocardial infarction
J Cardiovasc Comput Tomogr. 5(1):63-5, 2011
Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M, Saito Y
Morphological features of coronary arteries in patients with coronary spastic angina: Assessment with intracoronary optical coherence tomography.
Int J Cardiol. 146(3):334-40, 2011 Epub 2009 Aug 27
■ 国際学会発表
Somekawa S, Hayashi H, Sakabe M, Ioka T, Sato G, Inada K, Uemura S, Nakagawa O, Saito Y
Tmem100, A Novel BMP-dependent Endothelial Gene Essential for Arterial Development and Morphogenesis.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Kawata H, Soeda T, Takemoto Y, Sung JH, Uesugi Y, Tabata Y, Umaki K, Kato K, Uemura S, Saito Y
Development of thrombus-targeting, stealth type nanoparticles reactivated by ultrasound for coronary thrombolysis.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Ishigami K, Uemura S, Sugawara Y, Sung J, Soeda T, Okayama S, Kawata H, Horii M, Saito Y
Safety and Usefullness of Frquency Domain Optical Coherence Tomography During Coronary Stent Implantation:A copmarison with Intravascular Ultrasound.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Wenes M, Deschoemaeker S, Serneels J, Zhuang Z, Simons M, Saito Y, De Palma M, Mazzone M
Tie2-expressing macrophages (TEMs) induced by PHD2 haplodeficiency prevents ischemic damage after limb ischemia and myocardial infarction by inducing collateral artery growth.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Soeda T, Kawata H, Sung JH, Matsumoto T, Nakagawa H, Okada S, Nishida T, Okayama S, Somekawa S, Ishigami K, Takeda Y, Kawakami R, Horii M, Uemura S, Saito Y
A New Pleiotropic Effect of Statin : Induction of CD39 Expression at Atherosclerotic Lesions in vivo and in vitro.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Okada S, Morimoto T, Ogawa H, Kanauchi M, Sakuma M, Soejima H, Nakayama M, Doi N, Kubo A, Akai Y, Kawano T, Jinnouchi H, Waki M, Sugiyama S, Uemura S, Saito Y
Longer History of Diabetes Attenuates Benefit of Low-Dose Aspirin for Primary Prevention of Cardiovascular Events: A subanalysis from the JPAD Trial.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Okada S, Morimoto T, Ogawa H, Sakuma M, Soejima H, Nakayama M, Doi N, Kubo A, Akai Y, Kawano T, Jinnouchi H, Waki M, Sugiyama S, Uemura S, Saito Y
Is Aspirin Beneficial for Primary Prevention of Cardiovascular Events in High-Risk Diabetic Patients? -Insights from the JPAD Trial.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Matsumoto T, Uemura S, Matsui M, Seno A, Onoue K, Takeda Y, Horii M, Saito Y
Elevated Ratio of Placental Growth Factor to Soluble Fms-Like Tyrosine Kinase-1 Predicts an Adverse Outcome in Patients with Chronic Coronary Artery Disease.
American Heart Association Scientific Session 2011
November 12-16 (Orland, USA)
Matsui M, Uemura S, Takeda Y, Matsumoto T, Seno A, Nakatani K, Akai Y, Iwano M, Saito Y
Endogenous Anti-Atherosclerotic Property is Decreased in Patients with Renal Dysfunction: Evaluation From the Circulating Soluble Fms-Like Tyrosine Kinase-1 Level After Heparin Injection.
The 44th Annual Meeting of the American Society of Nephrology 2011
November 8- 13 (Philadelphia, USA)
Kitabata H, Takarada S, Tsujioka H, Kashiwagi M, Shiono Y, Shimamura K, Orii M, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Takemoto K, Ishigami K, Soeda T, Kimura K, Hirata K, Mizukoshi M, Imanishi T, Uemura S, Saito Y, Akasaka T
Effect of rosuvastatin on coronary fibrous cap thickness in patients with acute coronary syndrome: serial optical coherence tomography study.
The 60th Scientific Meeting of American College of Cardiology, 2011
April 2-5 (New Orleans, USA)
■ 受 賞
第28回国際心臓研究学会（ISHR） Young Investigator Award 優秀賞
染川 智
「Tmem100, a novel BMP9 and BMP10-dependent endothelial gene essential for proper arterial differentiation」
日本オランダJoint Seminar （JSPS-NOW Joint Seminar） Best Young Investigator Award
染川 智
「A novel downstream gene of BMP/ALK1 signaling pathway essential for proper arterial development」
AHA2011 The ATVB Young Investigator Award finalist
染川 智
「Tmem100, A Novel BMP-dependent Endothelial Gene Essential for Arterial Development and Morphogenesis」
武田科学振興財団2011年度医学系研究奨励金
染川 智
「動脈発生に必須の新規小胞体膜蛋白の血管発生および成熟臓器機能制御における意義」
第9回Metabolic Syndrome Conference 若手研究奨励賞
岡田定規
「糖尿病患者における低用量アスピリンの心血管疾患一次予防効果は糖尿病の病期によって異なる」
厳橿学術奨励賞
中川 仁
平成23年度奈良県医師会学術奨励賞
岡山悟志
平成23年度日本腎臓財団公募助成 腎不全病態研究助成
中谷公彦
「慢性腎臓病における血管石灰化に対するα-Klotho-FGF23系シグナルの役割」
|
2010年度/研究業績 |
■ 原 著
Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Horiuchi M, Murray M, Nakao K
Vasodilator therapy with hydralazine induces angiotensin AT receptor-mediated cardiomyocyte growth in mice lacking guanylyl cyclase-A.
Br J Pharmacol. 159(5):1133-42, 2010
Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K
Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity.
Metabolism. 59(9):1241-51, 2010
Uesugi Y, Kawata H, Jo J, Saito Y, Tabata Y
An ultrasound-responsive nano delivery system of tissue-type plasminogen activator for thrombolytic therapy.
J Control Release. 15;147(2):269-77, 2010
Uemura S, Onoue K, Saito Y
Response to Letter Regarding Article, ''Reduction of Circulating Soluble fms-Like Tyrosine Kinase-1 Plays a Significant Role in Renal Dysfunction-Associated Aggravation of Atherosclerosis''
Circulation. 122:e417, 2010
Harada K, Akai Y, Sakan H, Yamaguchi Y, Nakatani K, Iwano M, Saito Y
Resolution of mesangial light chain deposits 3 years after high-dose melphalan with autologous peripheral blood stem cell transplantation.
Clin Nephrol. 74(5):384-8, 2010
Okada S, Hiuge A, Makino H, Nagumo A, Takaki H, Konishi H, Goto Y, Yoshimasa Y, Miyamoto Y
Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes.
J Atheroscler Thromb. 17(8):828-33, 2010
Saito Y
Still Searching for a New Therapeutic Strategy for Acute Myocardial Infarction.
Circ J. 25;74(11):2290-2, 2010
Soejima H, Morimoto T, Saito Y, Ogawa H
Aspirin for the primary prevention of cardiovascular events in patients with peripheral artery disease or diabetes mellitus. Analyses from the JPAD, POPADAD and AAA trials.
Thromb Haemost. 104(6):1085-8, 2010
Saito Y.
Roles of atrial natriuretic peptide and its therapeutic use.
J Cardiol. 56(3):262-70, 2010
Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima Y.
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects.
Biochem Biophys Res Commun. 30;398(3):513-8, 2010
Onoue K, Zaima N, Sugiura Y, Isojima T, Okayama S, Horii M, Akai Y, Uemura S, Takemura G, Sakuraba H, Sakaguchi Y, Setou M, Saito Y.
Imaging Mass Spectrometry to Accurately Diagnose Fabry’s Disease.
Circ J. 24;75(1):221-3, 2010
Okayama S, Uemura S, Sugimoto H, Enomoto S, Onoue K, Omori S, Soeda T, Somekawa S, Ishigami K, Watanabe M, Nakajima T, Kubota Y, Saito Y
Dual Gradient-echo In-phase and Opposed-phase Magnetic Resonance Imaging to Evaluate Lipomatous Metaplasia in Patients with Old Myocardial Infarction.
Magn Reson Med Sci. 9(2):85-9, 2010
Okayama S, Uemura S, Soeda T, Seno A, Onoue K, Ishigami K, Horii M, Saito Y
Congenital isolated biventricular diverticula evaluated by cardiac computed tomography and magnetic resonance imaging.
Heart Lung Circ. 19(10):630-2, 2010
Okayama S, Fujimoto S, Tsutsumi T, Onoue K, Horii M, Uemura S, Sakaguchi Y, and Saito Y
A pediatric case of hypertrophic cardiomyopathy with mid-ventricular obstruction incidentally detected by electrocardiography.
JC Cases. 1(2):67-70, 2010
Nakatani K, Yoshimoto S, Iwano M, Asai O, Samejima K, Sakan H, Terada M, Hasegawa H, Nose M, Saito Y.
Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions: association with their severity and diversity in lupus models.
Am J Physiol Renal Physiol. 299(1):F207-16, 2010
Kubo A, Kim Y. H, Irion S, Kasuda S, Takeuchi M, Ohashi K, Iwano M, Dohi Y, Saito Y, Snodgrass R, Keller G
The Homeobox Gene HEX Regulates Hepatocyte Differentiation from ES cell-Derived Endoderm.
Hepatology. 51(2):633-41, 2010
Harada K, Miyamoto Y, Morisaki H, Ohta N, Yamanaka I, Kokubo Y, Makino H, Harada-Shiba M, Okayama A, Tomoike H, Okamura T, Saito Y, Yoshimasa Y, and Morisaki T
A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia.
J Atheroscler Thromb. 26;17(2):131-40, 2010
Okayama S, Uemura S, Soeda T, Horii M, Saito Y
Role of cardiac computed tomography in planning and evaluating percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy.
J Cardiovasc Comput Tomogr. 4(1):62-5, 2010
Okayama S, Uemura S, Watanabe M, Morikawa Y, Onoue K, Soeda T, Iwama H, Somekawa S, Takeda Y, Uramoto H, Kobayashi Y, Saito Y
Novel application of black-blood echo-planar imaging to the assessment of myocardial infarction.
Heart and Vessel. 25(2):104-12, 2010
Okayama S, Kawata H, Sung JH, Okada S, Nishida T, Onoue K, Soeda T, Uemura S, and Saito Y
Dual-single photon emission computed tomography and contrast-enhanced magnetic resonance imaging to evaluate dissimilar features of apical hypertrophic cardiomyopathy.
Cardiol J. 17(3):306-11, 2010
■ 国際学会発表
Asai O, Nakatani K, Sakan H, Samejima K, Yoshimoto S, Tanaka T, Yamaguchi Y, Akai Y, Iwano M, Imura A, Nabeshima Y, Saito Y
Decline of Renal Klotho Expression Is Associated with Hypercalciuria in Patients with Diabetes.
The 43th Annual Meeting of the American Society of Nephrology 2010
November 16- 21 (Denver, USA)
Uemura S, Ishigami K, Soeda T, Sung J, Nakagawa H, Tsutsumi T, Okayama S, Kawata H, Horii M, Saito Y
Optical Coherence Tomography-Based Complex Plaque Characteristics Predict the Subsequent Progression of Non-culprit Lesion in Patients with Percutaneous Coronary Intervention.
American Heart Association Scientific Session 2010
November 13-17 (Chicago, USA)
Kawata H, Soeda T, Takemoto Y, Sung J, Uemura S, Uesugi Y, Jo J, Tabata Y, Umaki K, Kato K, Saito Y
Development of the New Drug Delivery System with Ultrasound for Coronary Thrombosis.
American Heart Association Scientific Session 2010
November 13-17 (Chicago, USA)
Ishigami K, Uemura S, Sung J, Soeda T, Okayama S, Kawata H, Horii M, Saito Y
Better Neointimal Formation of Paclitaxel Eluting Stent of the Patient with Multiple Risk Factor -Optical coherence tomography study-.
American Heart Association Scientific Session 2010
November 13-17 (Chicago, USA)
Okada S, Morimoto T, Ogawa H, Nakayama H, Sakuma M, Uemura S, Kanauchi M, Doi N, Jinnouchi H, Soejima H, Sugihara S, Waki M, Kawano T, Saito Y
Efficacy of Low-dose Aspirin Therapy for Primary Prevention of Atherosclerotic Events Depends on the Severity of Diabetes: a subanalysis of JPAD trial.
American Heart Association Scientific Session 2010
November 13-17 (Chicago, USA)
Nakagawa H, Uemura S, Horii M, Ishigami K, Soeda T, Sung J, Somekawa S, Okayama S, Morikawa Y, Mizuno Y, Harada E, Yasue H, Saito Y
Diffuse Intimal Thickness without Lipid or Calcium Content at Branch Points is a Characteristic Feature of Coronary Artery in Patitents with Coronary Spastic Angina : Optical Coherence Tomography Analysis.
American Heart Association Scientific Session 2010
November 13-17 (Chicago, USA)
Inoue F, Uejima K, Fujimoto T, Kihyon A
Angina: Virtual Histology Intravascular Ultrasound Study Effect of Angiotensin Receptor Blockade on the Coronary Plaque Component in Patients With Stable Angina: Virtual Histology Intravascular Ultrasound Study.
American Heart Association Scientific Session 2010
November 13-17 (Chicago, USA)
Uemura S, Onoue K, Iwama H, Takeda Y, Somekawa S, Saito Y
Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Iwano M, Yamaguchi Y, Kimura K, Saito Y
Mechanisms of progression of glomerular injury.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Okada S, Masuzaki H, Kozuka C, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Hosoda K, Sakaue H, Kobori H, Kim J B, Saito Y, Nakao K
Dysregulation of Adipose Tissue Angiotensinogen by Oxidative Stress in Obesity.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Yamaguchi Y, Iwano M, Suzuki D, Nakatani K, Kimura K, Harada K, Kubo A, Akai Y, Toyoda M, Kanauchi M,Neilson G E, Saito Y
Epithelial-mesenchymal transition as an explanation for podocyte depletion in diabetic nephropathy.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Nakatani K, Asai O, Sakan H, Samejima K, Yoshimoto S, Tanaka T, Imura A, Akai Y, Iwano M, Nabeshima Y, Saito Y
Prolonged Hypoxia is related with Klotho expression decrease in kidney of diabetic nephropathy at early stages.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Somekawa S, Hitoshi N, Matsumoto T, Sung J H, Nishida T, Soeda T, Takemoto Y, Onoue K, Okayama S, Ishigami K, Takeda Y, Kawata H, Horii M, Uemura S, Saito Y
GC-A Signaling Attenuates Salt Toxicity on Aldosterone-Induced Cardiac Remodeling.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nishida T, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, Nakajima T, Akai Y, Iwano M, Saito Y
Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Horii M, Uemura S, Takitsume A, Nakagawa H, Tsutsumi T, Matsumoto T, Matsui M, Sung J H, Okada S, Nishida T, Soeda T, Yamaguchi Y, Okayama S, Somekawa S, Ishigami K, Kawata H, Saito Y
Plasma Amino-terminal Pro-BNP Level is More Closely Related both with Ejection Fraction and Estimated Glomerular Filtration Rate in Patients with Renal Dysfunction than BNP.
Horii M, Uemura S, Iwama H, Takeda Y, Imagawa K, Ishizashi H, Matsumoto M, Uemura M, Fujimura Y, Saito Y
Acute Myoardial Infarctiom as a Systemically Prothrombotic Condition Evidenced by Increased Ratio of von Willebrand Factor to ADAMTS13.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Takeda Y, Oliveira leite D R, Roncal C, Finisguerra V, Costa S, Janssens T, Debeckere K, Deschoemaeker S, Joedan B, Gallez B, Zhuang Z, Simons M, Saito Y, Carmeliet P, Mazzone M
Macrophage polarization induced by PHD2 haplodeficiency prevents ischemic damage by inducing arteriogenesis.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Kubo A,Takeuchi M, Kasuda S, Iwano M, Snodgrass R, Keiller G, Saito Y
The Homebox Gene HEX Regulates Hepatocyte Differentiation from ES cell-Derived Endoderm.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nshida T, Morikawa Y, Nakagawa H, Tsutsumi T, Sung J H, Takemoto Y, Soeda T, Okayama S, Ishigami K, Kawata H, Horii M, Nakajima T, Saito Y
Usefulness of Soluble Fms-like Tyrosine Kinase 1 as a Biomarker of Acute Severe Heart Failure in Patients with Acute Myocardial Infarction.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Kawata H, Soeda T, Sung J H, Takemoto Y, Umaki K, Kato K, Uemura S, Saito Y
Development of the New Ultrasound Device for Coronary Sonothrombolysis and its Facilitation of Thrombolysis in Swine Model of Acute Coronary Syndrome.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Soeda T, Kawata H, Sung J H, Nishida T, Okayama S, Somekawa S, Ishikgami K, Horii M, Uemura S, Saito Y
Atherosclerotic Plaque Volume Estimation by Intravascular Optical Coherence Tomography.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Kimura K, Iwano M, Yamaguchi Y, Nakatani K, Kubo A, Akai Y, Saito Y
Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
Asai O, Nakatani K, Sakan H, Samejima K, Yoshimoto S, Tanaka T, Imuira A, Akai Y, Iwano M, Nabeshima Y, Saito Y
klotho expression decline in kidney was associated with hypercalciuria in diabetic nephropathy.
International Symposium on Cardiovascular Endocrinology and Metabolism (CVEM) 2010
March 31-April 1 (Nara,Japan)
■ 受 賞
第14回日本心血管内分泌代謝学会学術総会 国際心血管代謝内分泌学会 CVEM2010
Travel award /Poster award
竹田征治
「Macrophage polarization induced by PHD2 haplodeficiency prevents ischemic damage by inducing arteriogenesis」
平成恵22年度万有生命科学振興国際交流財団 Banyu Foundation Research Grant
染川 智
「右心不全に関与する新規遺伝子の同定と機能解析」
第8回Metabolic Syndrome Conference 若手研究奨励賞
山口通雅
「糖尿病性腎症におけるポドサイトの上皮-間葉移行はポドサイト減少の原因となる」
日本内科学会 第23回内科学会奨励賞
尾上健児
「心腎連関分子メカニズム―可溶型Flt-1の腎不全における動態と補充療法による動脈硬化進展抑制の可能性」
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2009年度/研究業績 |
■ 原 著
Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Imagawa K, Nishida T, Morikawa Y, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, Nakajima T, Akai Y, Iwano M, Saito Y
Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis.
Circulation. 15;120(24):2470-7, 2009
Motoyama H, Ogawa S, Kubo A, Miwa S, Tagawa Y, Miyagawa S
In vitro reprogramming of adult hepatocytes into insulin-producing cells without
viral vectors.
Biochem Biophys Res Commun. 385:123-8, 2009
Takaoka M, Nagata D, Kihara S, Shimomura I, Kimura Y,Tabata Y, Saito Y, Nagai R, and Sata M
Periadventitial adipose tissue plays a critical role in vascular remodeling.
Circ Res. 105(9):906-11, 2009
Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nishida T, Morikawa Y, Nakagawa H, Tsutsumi T, Sung J. H, Takemoto Y, Soeda T, Okayama S, Ishigami K, Kawata H, Horii M, Nakajima T, Saito Y
Usefulness of soluble Fms-like tyrosine kinase 1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction.
Am J Cardiol. 104(11):1478-83, 2009
Ishigami K, Uemura S, Morikawa Y, Soeda T, Okayama S, Nishida T, Takemoto Y, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y
Long term follow-up of neointimal coverage of sirolimus-eluting stents: Evaluation with optical coherencetomography.
Circ J. 3(12):2300-7, 2009
Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M, Saito Y
Morphological features of coronary arteries in patients with coronary spastic angina: Assessment with intracoronary optical coherence tomography.
Int J Cardiol. 146(3):334-40, 2011 Epub 2009 Aug 27
Yamaguchi Y, Iwano M, Suzuki D, Nakatani K, Kimura K, Harada K, Kubo A, Akai Y, Toyoda M, Kanauchi M, Eric G Neilson, SaitoY
Epithelial-mesenchymal transition as an explanation for podocyte depletion in diabetic nephropathy.
Am J Kidney Dis. 54(4):653-64, 2009
Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K
Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.
Endocrinology. 150(8):3759-65, 2009
Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa S, Takeda Y, Uemura S, Matsumoto M, Fujimura Y, Jo J, Kimura Y, Tabata Y, Saito Y
Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis.
Arterioscler Thromb Vasc Biol. 29(6):857-862, 2009
Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S, Mochizuki N, Saito Y
Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.
Endocrinology. 50(7):3110-7, 2009
Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Takaoka M, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y
Treatment with recombinant placental growth factor (PlGF) enhances both angiogensis and arteriogenesis and improves survival after myocardial infarction.
Circ J. 73(9):1674-82, 2009
Nakagawa H, Morikawa Y, Mizuno Y, Harada E, Ito T, Matsui K, Saito Y, Yasue H
Coronary Spasm Preferentially Occurs at Branch Points: An Angiographic Comparison With Atherosclerotic Plaque.
Circ Cardiovasc Intervent. 2:97-104, 2009
Okayama S, Matsui M, Somekawa S, Iwano M, Saito Y
Non-contrast MRI for the evaluation of hydronephrotic and dysfunctioning kidney secondary to testicular cancer.
Ren Fail. 31(2):153-158, 2009
■ 国際学会発表
Okayama S, Uemura S, Soeda T, Onoue K, Somekawa S, Ishigami K, Takeda Y, Watanabe M, Fujimoto S, Saito Y
Clinical Significance of Papillary Muscle Late Enhancement Detected via Cardiac Magnetic Resonance Imaging in Patients With Old Myocardial Infarction.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Somekawa S, Qingfen Zhang, Nakagawa H, Sung J, Nishida T, Soeda T, Takemoto Y, Onoue K, Okayama S, Ishigami K, Kawata H, Horii M, Uemura S, Saito Y
Guanylyl Cyclase-A Signaling Attenuates Salt Effect on Aldosterone -Induced Cardiac Remodeling.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Morimoto T, Ogawa H, Nakayama M, Uemura S, Kawauchi M, Doi N, Jinnouchi H, Soejima H, Sugiyama S, Waki M, Kawano T, Saito Y
Epidemiology of Hemorrhagic and Gastrointestinal Adverse Effects of Low-dose Aspirin for Primary Prevention of Atherosclerotic Events in Type 2 Diabetic Patients: Insights From JPAD Trial.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Nakajima T, Nishida T, Sugimoto H, Oomori S, Okayama S, Watanabe M, Naito M, Uemura S, Saito Y
Epicardial-side Conduction During Cavotricuspid Isthmus Ablation; Prevalence, Significance, and a Novel Sign 'Sigmoid Pattern' of Halo Catheter on the Tricuspid Annulus.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Morimoto T, Ogawa H, Nakayama M, Uemura S, Kawauchi M, Doi N, Jinnouchi H, Soejima H, Sugiyama S, Waki M, Kawano T, Saito Y
Either Aspirin or Statin Use is Beneficial for Primary Prevention of Atherosclerotic Events in Patients With Type 2 Diabetes: Insights From JPAD Trial.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Soejima H, Nakayama M, Morimoto T, Uemura S, Kanauchi M, Doi N, Jinnouchi H, Sugiyama S, Waki M, Saito Y, Ogawa H
Aspirin Reduces the Incidence of Stroke Events in Poorly Blood Pressure Controlled Patients With Type 2 Diabetes.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Matoba S, Matsubara H, Imaizumi T, Murohara T, Saito Y, Fukushima M
Long-Term Clinical outcome of Therapeutic Angiogenesis by Autologous Transplantation of Bone Marrow Mononclear Cells for Patients With Chronic Limb Ischemia - Results of the TACT Trial, Prognosis, Efficacy and Safety.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
Inoue F, Yamaguchi S, Ueshima K, Fujimoto T, Ann K, Morimoto K, Tanabe K
Coronary plaque characteristics in patients with type 2 diabetes: virtual histology intravascular ultrasound study.
American Heart Association Scientific Session 2009
November 14-18 (Orlando, USA)
■ 受 賞
第20回日本心血管画像動態学会 Imaging Award受賞
岡山悟志
「閉塞性肥大型心筋症に対する経皮的心室中隔焼灼術の治療計画と効果判定における心臓CTの役割」
第57回日本心臓病学会 YIA優秀論文賞
尾上健児
「Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis」
第7回Metabolic Syndrome Conference 若手研究奨励賞
浅井 修
「糖尿病性腎症におけるKlotho遺伝子の意義：早期腎症における低酸素を介するKlotho遺伝子の発現低下と尿中カルシウム排泄の増加」
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2008年度/研究業績 |
■ 原 著
Yasue H, Mizuno Y, Harada E, Itoh T, Nakagawa H, Nakayama M, Ogawa H, Tayama S, Honda T, Hokimoto S, Ohshima S, Hokamura Y, Kugiyama K, Horie M, Yoshimura M, Harada M,
Uemura S, Saito Y
Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers
J Am Coll Cardiol 51(18):1742-1748, 2008
Ogawa H, Nakayama M, Morimoto T, Uemura S, Kanauchi M, Doi N, Jinnouchi H, Sugiyama S, Saito Y
Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial.
JAMA.300(18):2134-41, 2008
Matoba S, Tatsumi T, Murohara T, Imaizumi T, Katsuda Y, Ito M, Saito Y, Uemura S, Suzuki H, Fukumoto S, Yamamoto Y, Onodera R, Teramukai S, Fukushima M, Matsubara H
Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia
Am Heart J. 156:1010-18, 2008
Horii M, Uemura S, Uemura M, Matsumoto M, Ishizashi H, Imagawa K, Iwama H, Takeda Y, Kawata H, Nakajima T, Fujimura Y, Saito Y
Acute Myocardial Infarction as a Systemic Prothrombotic Condition Evidenced by Increased von Willebrand Factor Protein Over ADAMTS13 Activity in Coronary and Systemic Circulation
Heart and Vessel 23(5):301-307, 2008
Harada K, Akai Y, Yamaguchi Y, Kimura K, Nishitani Y, Nakatani K, Iwano M, Saito Y
Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy
Nephrol Dial Transplant. 23(10):3152-9, 2008
Harada K, Akai Y, Koyama S, Ikenaka Y, Saito Y
A case of autoimmune hepatitis exacerbated by the administration of etanercept in the patient with rheumatoid arthritis
Clin Rheumatol. 27(8):1063-6, 2008
Kasuda S, Kubo A, Sakurai Y, Irion S, Ohashi K, Tatsumi K, Nakajima Y, Saito Y, Hakake K, Pipe SW, Shima M, Yoshioka A
Establishment of embryonic stem cells secreting human factor VIII for cell-based treatment of hemophilia A
J Thromb Haemost. 6(8):1352-9, 2008
Okayama S, Uemura S, Nishida T, Morikawa Y, Onoue K, Takemoto Y, Soeda T, Somekawa S, Ishigami K, Takeda Y, Horii M, Kawata H, Takaoka M, Nakajima T, Saito Y
Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris
J Atheroscler Thromb. 15(5):228-34, 2008
Okayama S, Hirai T, Yamashita N, Somekawa S, Iwano M, Uemura S, Kanauchi M, Saito Y
Contrast-enhanced ultrasonography with Sonazoid for evaluation of renal microcirculation
J Med Ultrasonics. 35:183-189, 2008
Okayama S, Uemura S, Kawata H, Horii M, Saito Y
Continuing improvement of cardiac sympathetic activity on 123I-MIBG scintigraphy in a patient with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation
J Nucl Cardiol.15(5):e31-4, 2008
Q Zhang, Saito Y, Naya N, Imagawa K, Somekawa S, Kawata H, Takeda Y, Uemura S, Kishimoto I, Nakao K
The Specific Mineralocorticoid Receptor Blocker Eplerenone Attenuates Left Ventricular Remodeling in Mice Lacking the Gene Encoding Guanylyl Cyclase-A
Hypertens Res. 31(6):1251-6, 2008
■ 国際学会発表
Ogawa H, Nakayama M, Morimoto T, Uemura S, Kanauchi M, Doi N, Sugiyama S, Saito Y
JPAD Trial: Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes trial
Late-Breaking Clinical Trials - American Heart Association Scientific Session 2008
November 8-12 (New Orleans, USA)
Onoue K, Uemura S, Takeda Y, Iwama H, Nishida T, Morikawa Y, Takemoto Y, Soeda T, Somekawa S, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, Nakajima T, Saito Y
Soluble Fms-like Tyrosine Kinase 1: Decreased Levels Promote Atherosclerosis in Renal Dysfunction while Exogenous Administration Reduces Atherosclerosis Progression
Late-Breaking Bisic Science - American Heart Association Scientific Session 2008
November 8-12 (New Orleans, USA)
Ishigami K, Uemura S, Morikawa Y, Soeda T, Okayama S, Takemoto Y, Kawata H, Horii M,
Saito Y
Long Term Follow-Up of Neointimal Coverage after Silorimus-Eluting Stent Implantation -Optical Coherence Tomography Study-
American Heart Association Scientific Session 2008
November 8-12 (New Orleans, USA)
Soeda T, Uemura S,Okayama S, Morikawa Y, Ishigami K, Nishida T, Takemoto Y, Somekawa S, Kawata H, Horii M, Nakajima T, Saito Y
Characterization of Coronary Atherosclerotic Plaque by Dual-Source Computed Tomography: Comparison with Intracoronary Optical Coherence Tomography
American Heart Association Scientific Session 2008
November 8-12 (New Orleans, USA)
Takemoto Y, Kawata H, Imagawa K, Soeda T, Somekawa S, Uemura S, Matsumoto M, Fujimura Y, Kimura Y, Tabata Y, Saito Y
Development of the new gene-eluting stent that prevents subacute in-stent thrombosis by enhancing E-NTPDase activity in injured artery
American Heart Association Scientific Session 2008
November 8-12 (New Orleans, USA)
Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa, S, Nishida T, Takeda Y, Kawata H, Horii M, Nakajima T, Saito Y
Morphological Characterization of Coronary Artery in Patients with Coronary Spastic Angina by Intravascular Optical Coherence Tomography
American Heart Association Scientific Session 2008
November 8-12 (New Orleans, USA)
Kubo A, Stull R, Takeuchi M, Bonham K, Gouon-Evans V, Iwano M, Sho M, Saito Y, Keller G, Snodgrass R
Forced expression of pdx1 and ngn3 in ES cell derived endoderm population induces pancreatic differentiation
6th Annual Meeting, International Society for Stem Cell Research 2008
June 11-14 (Philadelphia,USA)
Asai O, Nakatani K, Sakan H, Samejima K, Yoshimoto S, Harada K, Akai Y, Iwano M, Nabeshima Y, Saito Y
Reduced Klotho expression in kidney with early diabetic nephropathy via hypoxic states
The 41th Annual Meeting of the American Society of Nephrology 2008
November 4- 9 (Philadelphia, USA)
Yamaguchi Y, Iwano M, Kimura K, Harada K, Nakatani K, Kubo A, Akai Y, Saito Y
Podocyte expression of fibroblast specific protein 1 in patients with IgA nephropathy
The 41th Annual Meeting of the American Society of Nephrology 2008
November 4-9 (Philadelphia, USA)
■ 受 賞
平成20年度日本腎臓財団公募助成 腎不全病態研究助成
久保篤史
「胚性幹細胞を用いたエリスロポエチン産生細胞の固定とその産生制御についての検討」
第15回中島佐一学術研究奨励賞
中谷公彦
「腎疾患およびそれに伴う心血管病変の発症・進展機構に関する研究」
第12回日本心不全学会 最優秀ポスター賞
尾上健児
「Soluble Fms-like Tyrosine Kinase 1 (sFlt-1), A Candidate Molecule Involved in Pathophysiology of Cardio-Renal Connection」
第12回日本心不全学会学術集会 Young Investigator's Award
竹本康宏
「Development of E-NTPDase gene eluting stent that prevents subacute in-stent thrombosis without antiplatelet drugs」
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2007年度/研究業績 |
■ 原 著
Higgins DF，Kimura K，Bernhardt WM，Shrimanker N，Akai Y，Hohenstein B，Saito Y，
Johnson RS，Kretzler M，Cohen CD，Eckardt KU，Iwano M，Haase VH
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
J Clin Invest 117（12）：3810-3820，2007.
Kitakaze M, Asakura M, Kim J, Shintani Y, Asanuma H, Hamasaki T, Seguchi O, Myoishi M, Minamino T, Ohara T, Nagai Y, Nanto S, Watanabe K, Fukuzawa S, Hirayama A, Nakamura N, Kimura K, Fujii K, Ishihara M, Saito Y, Tomoike H, Kitamura S; J-WIND investigators.
Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials.
Lancet 370 (9597) : 1483-93, 2007
Saito Y.
Clinical pathology and treatment of Renin-Angiotensin system 1. Usefulness of blocking of the Renin-Angiotensin system in treatment of chronic heart failure.
Intern Med 46(16):1291-4, 2007.
Morimoto T，Nakayama M，Saito Y，Ogawa H
Aspirin for primary prevention of atherosclerotic disease in Japan
J Atheroscler Thromb 14（4）：159-166，2007．
Kawata H，Naya N，Takemoto Y，Uemura S，Nakajima T，Horii M，Takeda Y，Fujimoto S，Yamashita A，Asada Y，Saito Y
Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction
Circ J 71（10）：1643-1648，2007．
Nakatani K, Qu WM, Zhang MC, Fujii H, Furukawa H, Miyazaki T, Iwano M, Saito Y, Nose M,
Ono M.
A Genetic Locus Controlling Aging-sensitive Regression of B Lymphopoiesis in an Autoimmune-prone MRL/lpr Strain of Mice.
Scand J Immunol 66(6):654-61,2007.
Yoshimoto S, Nakatani K, Iwano M, Asai O, Samejima K, Sakan H, Terada M, Harada K, Akai Y, Shiiki H, Nose M, Saito Y.
Elevated levels of fractalkine expression and accumulation of CD16＋monocytes in glomeruli of active lupus nephritis
Am J Kidney Dis 50(1):47-58, 2007.
Tatsumi T, Ashihara E, Yasui T, Matsunaga S, Kido A, Sasada Y, Nishikawa S, Hadase M, Koide M, Nakamura R, Irie H, Ito K, Matsui A, Matsui H, Katamura M, Kusuoka S, Matoba S, Okayama S, Horii M, Uemura S, Shimazaki C, Tsuji H, Saito Y, Matsubara H.
Intracoronary transplantation of non-expanded peripheral blood-derived mononuclear cells promotes improvement of cardiac function in patients with acute myocardial infarction.
Circ J 71(8):1199-207, 2007.
Kimura K, Yamaguchi Y, Horii M, Kawata H, Yamamoto H, Uemura S, Saito Y.
ANP is Cleared Much Faster than BNP in Patients with Congestive Heart Failure.
Eur J Clin Pharmacol.63(7):699-702, 2007.
Kanauchi M, Kanauchi K, Inoue T, Kimura K, Saito Y.
Surrogate markers of insulin resistance in assessing individuals with new categories "prehypertension" and "prediabetes".
Clin Chem Lab Med 45(1):35-9, 2007.
Okayama S, Uemura S, Saito Y
Detection of infarct-related myocardial edema using cardiac diffusion-weighted magnetic resonance imaging.
Int J Cardiol Dec 17, 2007.
Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K.
Genetic Disruption of Angiotensin II Type 1a Receptor Improves Long-Term Survival of Mice With Chronic Severe Aortic Regurgitation.
Circ J 71(8):1310-6, 2007.
Nishijima T, Nakayama M, Yoshimura M, Abe K, Yamamuro M, Suzuki S, Shono M, Sugiyama S, Saito Y, Miyamoto Y, Nakao K, Yasue H, Ogawa H.
The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm.
Pharmacogenet Genomics 17(8):581-587, 2007.
Shimasaki Y, Saito Y, Yoshimura M, Kamitani S, Miyamoto Y, Masuda I, Nakayama M, Mizuno Y, Ogawa H, Yasue H, Nakao K.
The effects of long-term smoking on endothelial nitric oxide synthase mRNA expression in human platelets as detected with real-time quantitative RT-PCR.
Clin Appl Thromb Hemost 13(1):43-51, 2007.
Kuratomi S, Kuratomi A, Kuwahara K, Ishii TM, Nakao K, Saito Y, Takano M.
NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
Biochem Biophys Res Commun 353(1):67-73, 2007.
■ 国際学会発表
Takeda Y, Uemura S, Iwama H, Naya N, Imagawa K, Nishida T, Onoue K, Takemoto Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y
Angiogenesis, but not vasculogenesis, plays major role in placental growth factor (PlGF) mediated improvement of cardiac function after myocardial infarction
American Heart Association Scientific Session 2007
November 4-7 (Orlando, USA)
Okayama S, Uemura S, Onoue K, Takemoto Y, Somekawa S, Ishigami K, Takeda Y, Kawata H, Horii M, Nakajima T, Saito Y
Infarct-Related Myocardial Edema Detected by Diffusion-Weighted Imaging; Comparison with T2-Weighted imaging
American Heart Association Scientific Session 2007
November 4-7 (Orlando, USA)
Onoue K, Takemoto Y, Iwama H, Somekawa S, Okayama S, Ishigami K, Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S, Saito Y
Plasma Level of Soluble Fms-like Tyrosine Kinase 1 (sFlt-1) as a Predictive Marker of Acute Severe Heart Failure in Patients with Acute Myocardial Infarction
American Heart Association Scientific Session 2007
November 4-7 (Orlando, USA)
Harada K, Akai Y, Yamaguchi Y, Kimura K, Nakatani K, Iwano M, Kanauchi M, Saito Y
Significance of renal biopsy for the patients with "presumed" diabetic nephropathy
The 40th Annual Meeting of the American Society of Nephrology
November 2-5 (San Francisco, USA)
Harada K, Akai Y, Yamaguchi Y, Kimura K, Nakatani K, Iwano M, Kanauchi M, Saito Y
Hemofiltration during coronary angiography is not a useful modality to prevent radiocontrast-induced nephropathy in chronic kidney disease
The 40th Annual Meeting of the American Society of Nephrology
November 2-5 (San Francisco, USA)
Harada K, Akai Y, Asai O, Yamaguchi Y, Horii M, Uemura S, Saito Y
Phosphate overload causes coronary in-stent restenosis in chronic hemodialysis patients
The 40th Annual Meeting of the American Society of Nephrology
November 2-5 (San Francisco, USA)
Yamaguchi Y, Iwano M, Kimura K, Harada K, Nakatani K, Kubo A, Akai Y, Kanauchi M, Saito Y
Podocyte expression of integrin-linked kinase in diabetic nephropathy promotes podocyte depletion via induction of epithelial-mesenchymal transition in podocytes
The 40th Annual Meeting of the American Society of Nephrology
November 2-5 (San Francisco, USA)
Yoshimoto S, Nakatani K, Hasegawa H, Asai O, Samejima K, Harada K, Akai Y, Iwano M, Nose M, Saito Y
Fractalkine preferentially contributes to the progression rather than the initiation of proliferative lupus nephritis in experimental lupus models
The 40th Annual Meeting of the American Society of Nephrology
November 2-5 (San Francisco, USA)
Samejima K, Nakatani K, Yoshimoto S, Asai O, Harada K, Akai Y, Iwano M, Saito Y
Podocyte expression of fibroblast-specific protein 1 (FSP1) is associated with the resistance to therapy and renal prognosis in membranous nephropathy
The 40th Annual Meeting of the American Society of Nephrology
November 2-5 (San Francisco, USA)
■ 受 賞
第１１回日本心血管内分泌代謝学会 Young Investigator Award
染川 智
「アルドステロン合成に関与する新規転写メカニズム：転写抑制因子NRSFの関与」
第52回日本透析医学会学術集会・総会 ゴールデンリボン賞
原田幸児
「慢性維持透析患者に対する冠動脈内留置ステント再狭窄に関する検討」
上原記念生命科学財団平成18年度研究奨励金
久保 篤史
「胚性幹細胞における内胚葉から肝細胞への分化誘導と細胞治療の試み」
上原記念生命科学財団平成18年度研究奨励金
第5回 Cardiac Translational Research Conference clinical competition優秀賞
尾上 健児
「Plasma Level of Soluble Fms-like Tyrosine Kinase 1(sFlt-1) as a predictive Marker of Acute Severe Heart Failure in Patient with Acute Myocardial Infarction」
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2006年度/研究業績 |
■ 原 著
Iwama H, Naya N, Imagawa K, Takemoto Y, Asai O, Onoue K, Okayama S, Somekawa S, Kida Y,
Takeda Y, Takaoka H, Kawata M, Horii M, Nakajima T, Doi N, Saito Y.
Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction.
J. Am. Coll. Cardiol. 47: 1559-67, 2006.
Takaoka M, Uemura S, Kawata H, Imagawa K, Takeda Y, Nakatani K, Naya N, Horii M, Yamano S,
Miyamoto Y, Yoshimasa Y, and Yoshihiko S.
Inflammatory response to acute myocardial infarction augments neointimal hyperplasia after vascular injury in a remote artery.
Arterioscler Thromb Vasc Biol. 26: 2083-9, 2006.
Imagawa K, Okayama S, Takaoka M, Kawata H, Naya N, Nakajima T, Horii M, Uemura S, Saito Y.
Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells.
J. Cardiovasc. Pharmacol. 47: 133-8, 2006.
Watanabe M, Uemura S, Iwama H, Okayama S, Takeda Y, Kawata H, Horii M, Nakajima T,
Hirohashi S, Kichikawa K, Ookura A, Saito Y.
Usefulness of 16-slice multislice spiral computed tomography for follow-up study of coronary stent implantation.
Circ. J. 70: 691-7, 2006.
Okayama S, Imagawa K, Noriyuki N, Iwama H, Somekawa S, Kawata H, Horii M, Nakajima T,
Uemura S, Saito Y.
Blocking T-type Ca2+ channels with Efonidipine Decreased Plasma Aldosterone Concentration in Healthy Volunteers.
Hypertens. Res. 29: 493-7, 2006.
Kanauchi M, Kanauchi K, Kimura K, Inoue T, Saito Y.
Utility of elevated 2-hour postload plasma glucose as an alternative to elevated fasting glucose as a criterion for the metabolic syndrome.
Metabolism. 55: 1323-6, 2006.
Kanauchi M, Kanauchi K, Kimura K, Inoue T, Saito Y.
Associations of chronic kidney disease with the metabolic syndrome in non-diabetic elderly.
Nephrol Dial Transplant. 2006.
Nakagawa Y, Kuwahara K, Harada M, Takahashi N, Yasuno S, Adachi Y, Kawakami R,
Nakanishi M, Tanimoto K, Usami S, Kinoshita H, Saito Y, Nakao K.
Class II HDACs mediate CaMK-dependent signaling to NRSFin ventricular myocytes.
J. Mol. Cell Cardiol. 2006.
Nakayama M, Yoshimura M, Sakamoto T, Abe K, Yamamuro M, Shono M, Suzuki S, Nishijima T,
A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine.
Pharmacogenet. Genomics. 16: 339-45, 2006.
Yamamuro M, Yoshimura M, Nakayama M, Abe K, Shono M, Suzuki S, Sakamoto T, Saito Y,
Nakao K, Yasue H, Ogawa H.
Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium.
Endocrinology. 147: 1314-21, 2006.
Mizuno R, Fujimoto S, Saito Y, Nakamura S.
Non-Invasive Quantitation of Myocardial Fibrosis Using Combined Tissue Harmonic Imaging and Integrated Backscatter Analysis in Dilated Cardiomyopathy.
Cardiology. 108: 11-17, 2006.
Kin T, Yamano S, Sakurai R, Kajitani M, Okahashi Y, Nishiura N, Saito Y, Ueno S.
Carotid Atherosclerosis is Associated with Brain Atrophy in Japanese Elders.
Gerontology. 53: 1-6, 2006.
■ 国際学会発表
Takeda Y, Uemura S, Iwama H, Naya N, Imagawa K, Onoue K, Takemoto Y, Okayama S,
Somekawa S, Takaoka M, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y.
Treatment with Recombinant Placental Growth Factor Enhances both Angiogensis and Arteriogenesis and Improves Survival after Myocardial Infarction.
American Heart Association Scientific Session 2006
November 12-15 (Chicago, USA)
Somekawa S, Imagawa K, Naya N, Uemura S, Saito Y.
Novel Mechanism of Aldosterone Synthesis: Critical Role of the Transcriptional Repressor NRSF System in Aldosterone Synthesis in Human Adrenocortical Cells (H295R).
American Heart Association Scientific Session 2006
November 12-15 (Chicago, USA)
Takaoka M, Uemura, S Kawata H, Imagawa K, Takeda Y, Nakatani K, Naya N, Horii M,
Yamano S, Saito Y.
Acute myocardial infarction augments neointimal hyperplasia at sites of angioplasty, not by increasing mobilization of bone marrow-derived cells, but by stimulating signaling via TNF-alpha, TNFR1 and IL-6.
American Heart Association Scientific Session 2006
November 12-15 (Chicago, USA)
Okayama S, Imagawa K, Naya N, Iwama H, Takeda Y, Uemura S, Saito Y.
Blockade of T-Type Calcium Channels Suppresses Cellular Synthesis and Plasma Levels of Aldosterone in Human.
American Heart Association Scientific Session 2006
November 12-15 (Chicago, USA)
Kimura K, Iwano M, Kubo A, Akai Y, Nakatani K, Harada K, Yamaguchi Y, Haase VH, Saito Y.
Inhibition of HIF-1 activity is a novel strategy for the treatment of tubulointerstitial fibrosis.
The 39th Annual Meeting of the American Society of Nephrology
November 14-19 (San Diego, USA)
Yamaguchi Y, Iwano M, Toyoda M, Nakatani K, Kimura K, Akai Y, Harada K, Suzuki D,
Kanauchi M, Neilson EG., Saito Y.
Podocyte expression of fibroblast-specific protein 1 in diabetic nephropathy of type 2 diabetes.
The 39th Annual Meeting of the American Society of Nephrology
November 14-19 (San Diego, USA)
Harada K, Akai Y, Nishitani Y, Yamaguchi Y, Kimura K, Yoshimoto S, Nakatani K, Nishino T,
Kanauchi M, Iwano M, Saito Y.
Prediction of corticosteroid responsiveness by the expression of fibroblast-specific protein 1 in the patients with IgA nephropathy.
The 39th Annual Meeting of the American Society of Nephrology
November 14-19 (San Diego, USA)
Yoshimoto S, Nakatani K, Asai O, Samejima K, Sakan H, Terada M, Akai Y, Iwano M,
Nose M, Saito Y.
The contribution of fractalkine to proliferative lupus nephritis via CD16+Mo infiltration.
The 39th Annual Meeting of the American Society of Nephrology
November 14-19 (San Diego, USA)
Samejima K, Nakatani K, Iwano M, Yoshimoto S, Asai O, Sakan H, Yamaguchi Y,
Kimura K, Harada K, Akai Y, Shiiki H, Neilson EG, Saito Y.
Podocyte expression of fibroblast-specific protein1 (FSP1) is a valuable tool for early diagnosis of focal segmental glomerulosclerosis.
The 39th Annual Meeting of the American Society of Nephrology
November 14-19 (San Diego, USA)
Iwama H, Uemura S, Naya N, Imagawa K, Onoue K, Takemoto Y, Okayama S, Somekawa S,
Takeda Y, Takaoka M, Kawata H, Horii M, Nakajima T, Saito Y.
Cardiac Expression of Placental Growth Factor stimulates peripheral mobilization of CD34+ progenitor cells in Patients with Myocardial Infarction.
American College of Cardiology 55th Annual Scientific Session
March 11−14 (Atlanta, USA）
■ 受 賞
財団法人 地域医学研究基金 平成18年度研究助成 最優秀賞
上村史朗
「急性心筋梗塞後の治癒機転における胎盤成長因子（PLGF）の役割
第54回日本心臓病学会学術集会 Young Investigator Award 最優秀賞
岩間 一
｢Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction ｣
平成18年度三井生命厚生事業団医学研究助成
岩野正之
「メタボリック症候群における心腎連関の重要性について（尿中FSP Iを指標として）」
平成18年度奈良県医師会学術奨励賞
中谷公彦
「糸球体病変の多様性とその重症度に対する血管内皮の接着分子の関与について−ループス腎炎モデルを用いて−」
平成18年度中島佐一学術研究奨励賞
赤井靖宏
「腎疾患進展機序に関する研究」
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2005年度/研究業績 |
■ 原 著
Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N, Saito Y,
Kangawa K, Mochizuki N.
Cyclic AMP potentiates VE-cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.
Mol. Cell Biol. 25: 136-46，2005．
Takahashi N, Saito Y, Kuwahara K, Harada M, Tanimoto K, Nakagawa Y, Kawakami R, Nakanishi M,
Yasuno S, Usami S, Yoshimura A, Nakao K.
Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.
J. Mol. Cell Cardiol. 38: 185-92, 2005．
Fukuhara S, Tomita S, Nakatani T, Yutani C, Kitamura S.
Endogenous bone-marrow-derived stem cells contribute only a small proportion of regenerated myocardium in the acute infarction model.
J. Heart Lung Transplant. 24: 67-72, 2005．
Danno D, Fujimoto S, Yamamoto Y, Mizuno R, Maeda K, Kanno M, Fujimoto T, Matsumura M,
Nakamura S.
Influence of patient/doctor relationship on the non-attendence rate of general practice, and investigation of reason for hospital non-attendance.
General Medicine 16： 17-21, 2005．
Saito Y.
Hypoglycemic attack: A rare triggering factor for takotsubo cardiomyopathy.
Intern. Med. 44: 171-2, 2005．
Shima Y, Iwano M, Yoshizaki K, Tanaka T, Kawase I, Nishimoto N.
All-trans-Retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice.
Nephron Exp Nephrol 100: 54-62, 2005.
Hamano K, Katafuchi T, Kikumoto K, Minamino N.
Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1.
Biochem. Biophys. Res. Commun. 330: 75-80, 2005.
Kanauchi M, Kimura K, Kanauchi K, Saito Y.
Beta-cell function and insulin sensitivity contribute to the shape of plasma glucose curve during an oral glucose tolerance test in non-diabetic individuals.
Int J Clin Pract 59: 427-32, 2005.
Abe K, Nakayama M, Yoshimura M, Nakamura S, Ito T, Yamamuro M, Sakamoto T,
Miyamoto Y, Yoshimasa Y, Saito Y, Nakao K, Yasue H, Ogawa H.
Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: relation with the -786T>C polymorphism.
Pharmacogenet Genomics 15: 29-36, 2005.
Matsumura N, Yamamoto K, Hirohashi R, Kitano S.
Renal tuberculosis mimicking hydronephrosis.
Intern. Med. 44: 768-，2005．
Nakanishi M, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Kawakami R, Nakagawa Y,
Tanimoto K, Yasuno S, Usami S, Li Y, Adachi Y, Fukamizu A, Garders DL, Nakao K.
Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice.
Hypertension 46: 441-7, 2005.
Somekawa S, Fukuhara S, Nakaoka Y, Fujita H, Saito Y, Mochizuki N.
Enhanced functional gap junction neoformation by protein kinase A-dependent and epac-dependent signal downstream of cAMP in cardiac myocytes.
Circ. Res. 97: 655-62, 2005.
Nishitani Y, Iwano M, Yamaguchi Y, Harada K, Nakatani K, Akai Y, Nishino T, Shiiki H, Kanauchi M,
Saito Y, Neilson EG.
Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN.
Kidney Int. 68: 1078-85, 2005.
Yamaji K, Fujimoto S, Ikeda Y, Masuda K, Nakamura S, Saito Y, Yutani C.
Apoptotic myocardial cell death in the setting of arrhythmogenic right ventricular cardiomyopathy.
Acta Cardiologica 60: 465-70, 2005.
Harada K, Akai Y, Iwano M, Nakatani K, Nishino T, Fujimoto T, Shiiki H, Saito Y.
Tubulointerstitial macrophage infiltration in a patient with hypokalemic nephropathy and primary Sjogren's syndrome.
Clin Nephrol 64: 387-90, 2005.
Biju MP., Akai Y, Shrimanker N, Haase VH.
Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent.
Am. J. Physiol. Renal Physiol. 289: F1217-26, 2005.
Tanimoto K, Saito Y, Hamanaka I, Kuwahara K, Harada M, Takanashi N, Kawakami R,
Nakagawa Y, Nakanishi M, Adachi Y, Shirakami G, Fukuda K, Yoshimura A and Nakano K.
SOCS1/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo.
Circ. J. 69: 1412-17, 2005.
Yamamura M, Yoshimura M, Nakayama M, Abe K, Shono M, Suzuki S, Sakamoto T, Saito Y,
Nakao K, Yasue H and Ogawa H.
Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extrcellular sodium.
Endocrinology 147: 1314-21, 2005..
■ 国際学会発表
Iwama H, Uemura S, Naya N, Imagawa K, Takaoka M, Kawata H, Takeda Y, Horii M,
Nakajima T, Doi N, Saito Y.
Cardiac over-expression of placental growth factor predicts the improvement of long-term left ventricular function in patients with acute myocardial infarction.
American College of Cardiology 54th Annual Scientific Session
March 6-9 (Orlando, USA)
Morimoto A, Cheng CP, Han QH, Hasegawa H, Little WC.
Altered ventricular and myocyte functional response to urotensin in heart failure.
America College of Caridology 54th Annual Scientific Session
March 6-9 (Orlando, USA)
Nishitani Y, Iwano M, Yamaguchi Y, Harada K, Nakatani K, Akai Y, Nishino T, Shiiki H, Kanauchi M, Saito Y, Neilson EG.
Fibroblast-Specific protein 1 is a specific prognostic marker for long-term renal survival in patients with IgA nephropathy.
18th Congress of the International Society of Nephrology
June 26-30 (Singapore, Singapore)
Kin T, Yamano S, Sakurai R, Kajitani M, Saito Y, Ueno S.
Carotid atherosclerosis is associatedwith brain atrophy in the East Asia population.
130th Annual Meeting of the American Neurological Association
September 25-28 (San Diego, USA)
Fujimoto S, Kawata H, Naya N, Takemoto Y, Saito Y.
Thrombolitic therapy with ultaround in acute coronary syndrome.
The 5th international symposium on therapeutic ultrasound
October 27-29 (Boston, USA)
Danno D, Kanno M, Fujimoto S, Nakamura S.
The usefulness of ultrasound irradiation when combined with rituximab; anti-CD-20 monoclonal antibody.
The 5th international symposium on therapeutic ultrasound
October 27-29 (Boston, USA)
Kimura K, Iwano M, Akai Y, Nakatani K, Harada K, Yamaguchi Y, Saito Y, Jahnson RS,
Neilson EG, Haase VH.
HIF-1α is a key molecule in the progression of EMT-mediated renal fibrosis.
The 38th Annual Metting of the American Society of Nephrology
November 8-13 (Philadelphia, USA)
Kawata H, Naya N, Takemoto Y, Uemura S, Nakajima T, Horii M, Takeda Y, Imagawa K, Fujimoto S,
Yamashita A, Asada Y, Saito Y.
The development of a new thrombolytic therapy with ultrasound in acute coronary syndrome.
American Heart Association Scientific Session 2005
November 13-16 (Dallas, USA)
Iwama H, Uemura S, Naya N, Imagawa K, Onoue K, Takemoto Y, Okayama S, Somekawa S,
Takeda Y, Takaoka M, Kawata H, Horii M, Nakajima T, Saito Y.
Cardiac over-expression of placental growth factor (PIGF) correlates to improvement of chronic phase left ventricular function in patients with myocardial infarction.
American Heart Association Scientific Session 2005
November 13-16 (Dallas, USA)
Mizuno R, Fujimoto S, Saito Y, Nakamura S.
Effect of low carbohydrate versus conventional low-caloric diets on left ventricular structure and function in severely obese young adult diet.
American Heart Association Scientific Session 2005
November 13-16 (Dallas, USA)
■ 受 賞
平成17年度日本心臓財団ファイザー賞
竹田征治
｢急性心筋梗塞のPIGF/Fｌｔ−１系の調節による新規血管新生療法の開発 ｣
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2004年度/研究業績 |
■ 原 著
Shiiki H, Saito T, Nishitani Y, Mitarai T, Yorioka N, Yoshimura A, Yokoyama H, Nishi S, Tomino Y,
Kurokawa K, Sakai H.
Research Group on Progressive Renal Diseases in Japan.
Prognosis and risk factors for idiopathic membranous nephropathy with nephritic syndrome in Japan.
Kidney Int. 65: 1400-7, 2004.
Nakatani K, Fujii H, Hasegawa H, Terada M, Arita N, MR. Ito, Ono M, Takahashi S,
Saiga K, Yoshimoto S, Iwano M, Shiiki H, Saito Y, Nose M.
Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.
Kidney Int. 65: 1290-300, 2004.
Kanauchi M, Kanauchi K, Hashimoto T, Saito Y.
Metabolic syndrome and new category 'pre-hypertension' in a Japanese population.
Curr. Med. Res. Opin. 20: 1365-70, 2004.
Iwano M, Neilson EG.
Mechanisms of tubulointerstitial fibrosis.
Curr. Opin. Nephrol. Hypertens. 13: 279-84, 2004.
Takeda Y, Mori T, Imabayashi H, Kiyono T, Gojo S, Miyoshi S, Hida N, Ita M, Segawa K,
Ogawa S, Sakamoto M, Nakamura S, Umezawa A.
Can the life span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation.
J. Gene. Med. 6: 833-45, 2004.
Uemura S, Watanabe M, Iwama H, Saito Y.
Extensive primary cardiac liposarcoma with multiple functional complications.
Heart 90: e48-49, 2004.
Nakashima T, Yamano S, Sasaki R, Minami S, Doi K, Yamamoto J, Takaoka M, Saito Y.
White-coat hypertension contributes to the presence of carotid arteriosclerosis.
Hypertens. Res. 27: 739-45, 2004.
Fujimoto S, Mizuno R, Saito Y, Nakamura S.
Clinical application of wave intensity for the treatment of essential hypertension.
Heart Vessels 19: 19-22, 2004.
Kanauchi M, Kimura K, Akai Y and Saito Y.
Insulin resistance and pancreatic beta-cell function in the patients with hypertensive kidney disease.
Nephrol. Dial. Transplant. 19: 2025-9, 2004.
Kakui K, Ito H, Sagawa N, Yura S, Korita D, Takemura M, Miyamoto Y, Saito Y,
Nakao K, Fujii S.
Augmented endothelial nitric oxide synthase (eNOS) protein ezpression in human pregnant myometrium:possible involvement of eNOS promoter activation by estrogen via both estrogen receptor (ER)α and ERβ.
Mol. Hum. Reprod. 2: 115-22, 2004.
Kawakami R, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Nakagawa Y, Nakanishi M,
Tanimoto K, Usami S, Yasuno S, Saito Y, Kinoshita H, Ogawa Y, Nakao K.
Overexpression of brain natriuretic peptide induces excessive matrix remodeling after acute myocardial infarction in mice.
Circ. 110: 3306-12, 2004.
Nakamura S, Yoshimura M, Nakayama M, Ito T, Mizuno Y, Harada E, Sakamoto T, Saito Y, Nakao K,
Yasue H, Ogawa H.
Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart.
Circ. 110: 1787-93, 2004.
Suzuki S, Yoshimura M, Nakayama M, Mizuno Y, Harada E, Ito T, Nakamura S, Abe K, Yamamuro M,
Sakamoto T, Saito Y, Nakao K, Yasue H, Ogawa H.
Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction: a long-term follow-up analysis.
Circ. 110: 1387-91, 2004.
Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Hamanaka I, Takahashi N, Kawakami R,
Tanimoto K, Nakagawa Y, Nakanishi M, Adachi Y, Garbers DL, Fukamizu A, Nakao K.
Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A.
Endocrinology 145: 951-8, 2004.
Nishizawa J, Matsumoto M, Sugita T, Matsuyama K, Tokuda Y, Yoshida K, Matsuo T, Okayama S,
Fujimoto S and Saito Y.
Intravenous leiomyomatosis extending into the right ventricle association with pulmonary metastasis and extensive arteriovenous fistula.
J. Am. Coll. Surg. 198: 842-3, 2004.
Adachi Y, Imagawa J, Suzuki Y, Yogo K, Fukazawa M, Kuromaru O, Saito Y.
G-CSF treatment increase side population cell infiltration after myocardial infarction in mice.
J. Mol. Cell. Cardiol. 36: 707-10, 2004.
■ 国際学会発表
Iwama H, Uemura S, Naya N, Imagawa K, Takaoka M, Kawata H, Horii M, Nakajima T,
Doi N, Saito Y.
Elevated plasma level of placental growth factor is correlated with peripheral monocyte fraction in patients with acute myocardial infarction.
American Heart Association Scientific Session 2004
November 7-10, 2004 (New Orleans, USA)
Iwama H, Uemura S, Naya N, Imagawa K, Takaoka M, Kawata H, Horii M, Nakajima T,
Doi N, Saito Y.
Elevated plasma level of placental growth factor is correlated with peripheral monocyte fraction in patients with acute myocardial infarction.
Annual Scientific Session 2004 of American college of cardiology
March 7-10, 2004 (New Orleans, USA)
■ 受 賞
平成16年度日本腎臓学会バクスター賞
西谷喜治
「腎間質線維化の進展には，FSP1陽性細胞とαSMA陽性細胞のどちらが重要か？」
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2003年度/研究業績 |
■ 原 著
Kanauchi M, Nakajima M, Kanauchi K and Saito Y.
Pancreatic beta-cell function and insulin sensitivity in Japanese subjects with impaired glucose tolerance and newly diabnosed type 2 deabetes mellitus.
Metabolism 52: 476-81, 2003.
Kanauchi M, Yamano S, Kanauchi K and Saito Y.
Homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index, and oral glucose insulin sensitivity index in nonobese, nondiabetic subjects with high-nomal blood pressure.
J. Clin. Endocrinol. Metab. 88: 3444-6, 2003.
Adachi Y, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Kawakami R, Nakanishi M,
Nakagawa Y, Tanimoto K, Saito Y, Yasuno S, Usami S, Iwai M, Horiuchi M, Nakao K.
Angiotensin type 2 reseptor deficiency exacerbates heart failure and reduces Servival following acute myocardial infarction in mice.
Circ. 107: 2406-8, 2003.
Takahashi N, Saito Y, Kuwahara K, Harada M, Kishimoto I, Ogawa Y, Kawakami R, Nakagawa Y,
Nakanishi M and Nakao K.
Angiotensin II-induced ventricular hypertrophy and extracelluar signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation.
Hypertens. Res. 26: 847-53, 2003.
Nakayama M, Yoshimura M, Sakamoto T, Shimasaki Y, Nakamura S, Ito T, Abe K, Yamamuro M,
Miyamoto Y, Saito Y, Nakao K, Yasue H and Ogawa H.
Synergistic interaction of T-786 → C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm.
Pharmacogenetics 13: 683-8, 2003.
Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y,
Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H,
Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S,
Saito Y, Harada M and Nakao K.
NRSF regulates fetal cardiac gene program and maintains normal cardiac structure and funcution.
EMBO. J. 22: 6310-21, 2003.
Kanauchi M.
Validation of the oral glucose insulin sensitivity index to assess insulin sensitivity in Japanese subjects for use in clinical practice.
Eur. J. Clin. Invest. 33: 1022-3, 2003.
Kanauchi M.
Obesity-related albuminuria and renal histology in patients with type 2 diabetes mellitus.
Nephrol. Dial. Transplant. 18: 849-50, 2003.
■ 国際学会発表
Nakatani K, Yoshimoto S, Fujii H, Terada M, Nagasaki M, Iwano M, Shiiki H, Saito Y,
Nose M.
Contribution of fractalkine expression to the development of experimental lupus nephritis.
17th World Congress of Nephrology(WCN) International Society of Nephrology
June 6-15, 2003（Berlin, Germany）
Adachi Y, Saito Y.
Granulocyte-colony stimulating factor (G-CSF) can augment the migration of the bone marrow-derived side population cells into infacted heart in mice.
76th Scientific Sessions of American Heart Association
November 9-12, 2003 (Orland, USA)
■ 受 賞
平成15年度中島佐一学術研究奨励賞
上村史朗
「冠動脈硬化症の進展機構の解明と治療に関する研究」
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】
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2002年度/研究業績 |
■ 原 著
Harada K, Akai Y, Kurumatani N, Iwano M and Saito Y.
Prognostic value of urinary interleukin 6 in patients with IgA nephropathy: an 8-year follow-up study.
Nephron 92: 824-6, 2002.
Kanauchi M, Motomiya K and Hashimoto T.
Insulin secretion and sensitivity in nonobese and obese Japanese patients with coronary artery disease.
Metabolism 51: 184-8, 2002.
Kanauchi M, Tsujimoto N and Hashimoto T.br> Validation of simple indices to assess insulin sensitivity based on the oral blucose tolerance test in the Japanese population.
Diabetes. Res. Clin. Pract. 55: 229-35, 2002.
Kanauchi M, Nishioka H and Hashimoto T.
Oxidative DNA damage and tubulointerstitial injury in diabetic nephropathy.
Nephron 91: 327-9, 2002.
Kanauchi M, Akai Y and Hashimoto T.
Transferrinuria in type 2 diabetic patients with early nephropathy and tubulointerstitial injury.
Eur. J. Intern. Med. 13: 190-3, 2002.
Kanauchi M.
Cigarette smoking affects tubulointerstitial lesion in type 2 diabetes.
Diabetes. Care. 25: 1486-7, 2002.
Kanauchi M.
A new index of insulin sensitivity obtained from the oral glucose tolerance test applicable to advanced type 2 diabetes mellitus.
Diabetes Care. 25: 1891-2, 2002.
Kanauchi M, Akai Y and Hashimoto T.
Validation of simple indices to assess insulin sensitivity and pancreatic beta-cell function in patients with renal dysfunction.
Nephron 92: 713-5, 2002.
Ogawa E, Saito Y, Kuwahara K, Harada M, Miyamoto Y, Hamanaka I, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Kishimoto I, Naruse Y, Mori N and Nakao K.
Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression.
Cardiovasc Res 53: 451-9, 2002.
Mizuno Y, Yasue H, Yoshimura M, Fujii H, Yamamoto N, Nakayama M, Harada E, Sakamoto T, Nakamura S, Ito T, Shimasaki Y, Ogawa H, Saito Y and Nakao K.
Effects of perindopril on aldosterone production in the failing human heart.
Am J Coll Cardiol 89: 1197-200, 2002.
Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Takahashi N, Kawakami R,Tanimoto K, Nakagawa Y, Nakanishi M, Adachi Y, Garbers DL, Fukamizu A, Nakao K.
Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart.
Circ 106: 1722-8, 2002.
■ 国際学会発表
Nakatani K, Yoshimoto S, Hasegawa H, Fujii H, Terada M, Iwasaki M, Iwano M,
Shiiki H, Nose M, Saito Y.
Soluble E-selection prevents the development of experimental lups nephritis induced by nephritogenic monoclonal antibody of MRL/lpr mice.
The 35th Annual Meeting of the American Society of Nephrology
November 1-4, 2002 (Philadelphia, USA)
■ 受 賞
平成14年度中島佐一学術研究奨励賞
岩野正之
「腎不全の進展機序に関する研究」
平成14年度奈良県医師会学術奨励賞
川田啓之
「急性心筋梗塞におけるischemic preconditioningの効果心保護作用と分子機序の解明」
［1研究テーマ］［2研究業務
【2012】【2011】【2010】【2009】【2008】【2007】【2006】
【2005】【2004】【2003】【2002】］［3留学システム］［4プレスリリース］ |
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