奈良県立医科大学 第二解剖教室 分子機能形態学講座
教育内容とシラバス研究内容業績ラボメンバーリンクアクセス
業績

発表論文リスト

2017年

  1. Nomura T, Bando Y, You H, Tanaka T, Yoshida S.
    Yokukansan reduces cuprizone-induced demyelination in the corpus callosum through anti-inflammatory effects on microglia.
    Neurochem Res. in press. PubMed
  2. Tanaka T, Murakami K, Bando Y, Nomura T, Isonishi A, Morita-Takemura S, Tatsumi K, Wanaka A, Yoshida S.
    Microglia support ATF3-positive neurons following hypoglossal nerve axotomy.
    Neurochem Int. 2017 Sep;108:332-342. PubMed
  3. Makinodan M, Ikawa D, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Yamauchi T, Okumura K, Komori T, Fukami SI, Yoshino H, Kanba S, Wanaka A, Kishimoto T.
    Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function.
    Sci Rep. 2017 Jul 14;7(1):5481. PubMed
  4. Ouji Y, Sakagami M, Omori H, Higashiyama S, Kawai N, Kitahara T, Wanaka A, Yoshikawa M.
    Efficient induction of inner ear hair cell-like cells from mouse ES cells using combination of Math1 transfection and conditioned medium from ST2 stromal cells. PubMed
  5. Manabe T, Wanaka A.
    Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells Using RNAi Directed Against Transcription Factor L3/Lhx8.
    Methods Mol Biol. 2017;1622:101-109. doi: 10.1007/978-1-4939-7108-4_8. PubMed
  6. Kayashima Y, Yamamuro K, Makinodan M, Nakanishi Y, Wanaka A, Kishimoto T.,
    Effects of Canon chord progression on brain activity and motivation are dependent on subjective feelings, not the chord progression per se.
    Neuropsychiatr Dis Treat. 2017 Jun 12;13:1499-1508. doi: 10.2147/NDT.S136815. eCollection 2017. PubMed
  7. Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
    Microglia-derived neuregulin expression in psychiatric disorders
    Brain Behav Immun. 2017 Mar;61:375-385. PubMed
  8. Nishikawa K, Furube E, Morita S, Horii-Hayashi N, Nishi M, Miyata S. Wanaka A, Kishimoto T.,
    Structural Reconstruction of the Perivascular Space in the Adult Mouse Neurohypophysis During an Osmotic Stimulation.
    J Neuroendocrinol. 2017 Feb;29(2). PubMed

2016年

  1. Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami SI, Yoshino H, Wanaka A, Kishimoto T.
    Social isolation impairs remyelination in mice through modulation of IL-6.
    FASEB J. 2016 Dec;30(12):4267-4274. PubMed
  2. Morita-Takemura S, Nakahara K, Tatsumi K, Okuda H, Tanaka T, Isonishi A, Wanaka A.
    Changes in endothelial cell proliferation and vascular permeability after systemic lipopolysaccharide administration in the subfornical organ.
    J Neuroimmunol. 2016 Sep 15;298:132-7. PubMed
  3. Takahashi H, Ogawa Y, Yoshihara S, Asahina R, Kinoshita M, Kitano T, Kitsuki M, Tatsumi K, Okuda M, Tatsumi K, Wanaka A, Hirai H, Stern PL, Tsuboi A.
    A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors.
    J Neurosci. 2016 Aug 3;36(31):8210-27 PubMed
  4. Tatsumi K, Okuda H, Morita-Takemura S, Tanaka T, Isonishi A, Shinjo T, Terada Y, Wanaka A.
    Voluntary Exercise Induces Astrocytic Structural Plasticity in the Globus Pallidus.
    Front Cell Neurosci. 2016 Jun 21;10:165 PubMed
  5. Nochioka K, Okuda H, Tatsumi K, Morita S, Ogata N, Wanaka A.
    Hedgehog signaling components are expressed in choroidal neovascularization in laser-induced retinal lesion.
    Acta Histochem Cytochem. 49(2):67-74. 2016 PubMed

2015年

  1. Okuda H, Tatsumi K, Morita-Takemura S, Nakahara K, Nochioka K, Shinjo T, Terada Y, Wanaka A.
    Hedgehog signaling modulates the release of gliotransmitters from cultured cerebellar astrocytes.
    Neurochem Res. 2016 Feb;41(1-2):278-89. PubMed
  2. Morita S, Furube E, Mannari T, Okuda H, Tatsumi K, Wanaka A, Miyata S.
    Heterogeneous vascular permeability and alternative diffusion barrier in sensory circumventricular organs of adult mouse brain.
    Cell Tissue Res. 2016 Feb;363(2):497-511 PubMed
  3. Nakano Y, Furube E, Morita S, Wanaka A, Nakashima T, Miyata S.
    Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain.
    J Neuroimmunol. 278:144-158. 2015 PubMed
  4. Morita S, Furube E, Mannari T, Okuda H, Tatsumi K, Wanaka A, Miyata S.
    Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain.
    Cell Tissue Res. 359:865-884. 2015 PubMed
  5. Shimomura T, Kawakami M, Okuda H, Tatsumi K, Morita S, Nochioka K, Kirita T, Wanaka A.
    Retinoic acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo.
    J Biosci Bioeng. 119:260-266. 2015 PubMed

2014年

  1. Furube E, Mannari T, Morita S, Nishikawa K, Yoshida A, Itoh M, Miyata S.
    VEGF- and PDGF-dependent dynamic neurovascular reconstruction in the neurohypophysis of adult mice.
    J Endocrinol. 222:161-179. 2014 PubMed
  2. Okuda H, Tatsumi K, Horii-Hayashi N, Morita S, Okuda-Yamamoto A, Imaizumi K, Wanaka A.
    OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex.
    J Neurochem.130:612-625. 2014 PubMed
  3. Kawakami M, Okuda H, Tatsumi K, Kirita T, Wanaka A.
    Inhibition of Wnt/β-catenin pathway by Dikkopf-1 affects midfacial morphogenesis in chick embryo.
    J Biosci Bioeng. 117:664-669. 2014 PubMed
  4. Okuda H, Tatsumi K, Morita S, Shibukawa Y, Korekane H, Horii-Hayashi N, Wada Y, Taniguchi N, Wanaka A.
    The chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes.
    J Biol Chem. 289:2620-2631. 2014 PubMed
  5. Morita S, Tatsumi K, Makinodan M, Okuda H, Kishimoto T, Wanaka A.
    Geissoschizine Methyl Ether, an Alkaloid from the Uncaria Hook, Improves Remyelination After Cuprizone-Induced Demyelination in Medial Prefrontal Cortex of Adult Mice.
    Neurochem Res. 39:59-67, 2014 PubMed

2013年

  1. Makinodan M, Okuda-Yamamoto A, Ikawa D, Toritsuka M, Takeda T, Kimoto S, Tatsumi K, Okuda H, Nakamura Y, Wanaka A, Kishimoto T.
    Oligodendrocyte plasticity with an intact cell body in vitro.
    PLoS One. 8:e66124, 2013 PubMed

2012年

  1. Matsuyoshi H, Takimoto K, Yunoki T, Erickson VL, Tyagi P, Hirao Y, Wanaka A, Yoshimura N.
    Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons.
    Life Sci. 91:258-263, 2012 PubMed
  2. Iseki K, Hagino S, Nikaido T, Zhang Y, Mori T, Yokoya S, Hozumi Y, Goto K, Wanaka A, Tase C.
    Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice.
    Biomed Res>. 33:345-353, 2012 PubMed

2011年

  1. Horii-Hayashi N, Yoshikawa M, Matsusue Y, Ishizaka S, Nishi M, Wanaka A
    Environmental stimulation changes tissue-type plasminogen activator activity in the adult mouse hippocampus.
    Neurochem Int 58:1-4, 2011 PubMed
  2. Murakami T, Hino S, Nishimura R, Yoneda T, Wanaka A, ImaizumiK.
    Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice.
    Bone 48:514-523, 2011 PubMed
  3. Kimoto S, Okuda A, Toritsuka M, Yamauchi T, Makinodan M, Okuda H, Tatsumi K, Nakamura Y, Wanaka A, Kishimoto T.
    Olanzapine stimulates proliferation but inhibits differentiation in rat oligodendrocyte precursor cell cultures.
    Prog Neuropsychopharmacol Biol Psychiatry. 35:1950-1956, 2011 PubMed

 

2010年

  1. Tatsumi K, Okuda H, Makinodan M, Yamauchi T, Makinodan E, Matsuyoshi H, Manabe T, Wanaka A. 
    Transient activation of Notch signaling in the injured adult brain. 
    J Chem Neuroanat. 39:15-19, 2010 PubMed
  2. Yamauchi T, Tatsumi K, Makinodan M, Kimoto S, Toritsuka M, Okuda H, Kishimoto T, Wanaka A. 
    Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus. 
    Neurochem Int. 57:565-571, 2010 PubMed
  3. Horii-Hayashi N, Tatsumi K, Matsusue Y, Okuda H, Okuda A, Hayashi M, Yano H, Tsuboi A, Nishi M, Yoshikawa M, Wanaka A. 
    Chondroitin sulfate demarcates astrocytic territories in the mammalian cerebral cortex. 
    Neurosci Lett. 483:67-72, 2010 PubMed
  4. Manabe T, Wanaka A. 
    Regulation and/or repression of cholinergic differentiation of murine embryonic stem cells using RNAi directed against transcription factor L3/Lhx8.
    Methods Mol Biol. 650:101-109, 2010 PubMed

2009年

  1. Murakami T, Saito A, Hino S, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, Imaizumi K. 
    Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. 
    Nat Cell Biol. 11(10):1205-11, 2009 PubMed
  2. Okuda H, Tatsumi K,Makinodan M, Yamauchi T, Kishimoto T, Wanaka A.
    Environmental enrichment stimulates progenitor cell proliferation in the amygdala.
    J Neurosci Res. 87:3546-53, 2009 PubMed
  3. Makinodan M, Yamauchi T, Tatsumi K, Okuda H, Yoshinobu N, Sadamatsu M, Kishim, oto T, Wanaka A 
    Yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia. 
    Journal of Brain Disease 1(1): 1-6, 2009
  4. Chihara K, Saito A, Murakami T, Hino S, Aoki Y, Sekiya H, Aikawa Y, Wanaka A, Imaizumi K. 
    Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. 
    J Neurochem. 110(3):956-65, 2009 PubMed
  5. Makinodan M, Yamauchi T, Tatsumi K, Okuda H,, Takeda T, Kiuchi K, Sadamatsu M, , Wanaka A,, Kishimoto T. 
    Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice.
    Prog Neuropsychopharmacol Biol Psychiatry. 33(6):978-85, 2009 PubMed
  6. Islam MS, Tatsumi K, Okuda H, Shiosaka S, Wanaka A. 
    Olig2-expressing progenitor cells preferentially differentiate into oligodendrocytes in cuprizone-induced demyelinated lesions. 
    Neurochem Int
    . 54(3-4):192-8, 2009 PubMed

2008年

  1. Horii-Hayashi N, Okuda H, Tatsumi K, Ishizaka S, Yoshikawa M, Wanaka A.
    Localization of chondroitin sulfate proteoglycan versican in adult brain with special reference to large projection neurons.
    Cell Tissue Res. 334(2):163-77, 2008 PubMed
  2. Makinodan M, Tatsumi K, Okuda H, Manabe T, Yamauchi T, Noriyama Y, Kishimoto T, Wanaka A.
    Lysophosphatidylcholine induces delayed myelination in the juvenile ventral hippocampus and behavioral alterations in adulthood.
    Neurochem Int. 53:374-81, 2008 PubMed>
  3. Tatsumi K, Takebayashi H, Manabe T, Tanaka K. Matsuyoshi H, Makinodan M, Yamauchi T, Makinodan E, Okuda H, Ikenaka K, Wanaka A
    Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex revealed preferential differentiation into astrocytes.
    J Neurosci Res. 86(16):3494-50, 2008 PubMed
  4. Makinodan M, Tatsumi K, Manabe T, Yamauchi T, Makinodan E, Matsuyoshi H, Shimoda S, Noriyama Y, Kishimoto T, Wanaka A.
    Maternal immune activation in mice delays myelination and axonal development in the hippocampus of the offspring.
    J Neurosci Res. 86(10):2190-200, 2008 PubMed
  5. Manabe T, Tatsumi K, Inoue M, Matsuyoshi H, Makinodan M, Yamauchi T, Makinodan E, Yokoyama S, Sakumura R, Okuda H, Wanaka A.
    Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheres.
    Int J Dev Neurosci.26(2):249-52, 2008 PubMed

2007年

  1. Hayashi N, Tatsumi K, Okuda H, Yoshikawa M, Ishizaka S, Miyata S, Manabe T, Wanaka A.
    DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain.
    Biochem Biophys Res Commun. 364(2):410-5, 2007 PubMed
  2. Makinodan E, Manabe T, Makinodan M, Yamauchi T, Matsuyoshi H, Sakumura R, Tatsumi K, Wanaka A.
    A novel role for Fyn: change in sphere formation ability in murine embryonic stem cells.
    Neuroscience 147(1):1-4, 2007 PubMed
  3. Johar K, Vasavada AR, Tatsumi K, Dholakia S, Nihalani B, Rao SS.
    Anterior capsular plaque in congenital cataract: occurrence, morphology, immunofluorescence, and ultrastructure.
    Invest Ophthalmol Vis Sci.48(9):4209-14, 2007 PubMed
  4. Manabe T, Tatsumi K, Inoue M, Makinodan M, Yamauchi T, Makinodan E, Yokoyama S, Sakumura R, Wanaka A.
    L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells.
    Cell Death Differ. 14(6):1080-5, 2007 PubMed

2006年

  1. Matsuyoshi H, Masuda N, Chancellor MB, Erickson VL, Hirao Y, de Groat WC, Wanaka A, Yoshimura N.
    Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder.
    Brain Res. 13;1119(1):115-23, 2006 PubMed
  2. Okuda H, Manabe T, Yanagita T, Matsuzaki S, Bando Y, Katayama T, Wanaka A, Tohyama M.
    Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina.
    Mol Cell Neurosci. 33(1):81-7, 2006 PubMed
  3. Inoue M, Kawakami M, Tatsumi K, Manabe T, Makinodan M, Matsuyoshi H, Kirita T, Wanaka A.
    Expression and regulation of the LIM homeodomain gene L3/Lhx8 suggests a role in upper lip development of the chick embryo.
    Anat Embryol (Berl).211(3):247-53, 2006  PubMed
  4. Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, Imaizumi K.
    Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress.
    J Neurochem. 96(4):1090-100, 2006 PubMed
  5. Shinoe T, Wanaka A, Nikaido T, Kakuta Y, Masunaga A, Shimizu J, Duyckaerts C, Imaizumi K, Iwamoto A, Kanazawa I.
    The pro-apoptotic human BH3-only peptide harakiri is expressed in cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients.
    Neurosci Lett. 393(2-3):102-7, 2006 PubMed

2005年

  1. Manabe T, Tatsumi K, Inoue M, Matsuyoshi H, Makinodan M, Yokoyama S, Wanaka A.
    L3/Lhx8 is involved in the determination of cholinergic or GABAergic cell fate.br /> J Neurochem. 94(3):723-30, 2005  PubMed
  2. Uemura M, Tatsumi K, Matsumoto M, Fujimoto M, Matsuyama T, Ishikawa M, Iwamoto TA, Mori T, Wanaka A, Fukui H, Fujimura Y.
    Localization of ADAMTS13 to the stellate cells of human liver.
    Blood 106(3):922-4, 2005 PubMed
  3. Tatsumi K, Haga S, Matsuyoshi H, Inoue M, Manabe T, Makinodan M, Wanaka A.
    Characterization of cells with proliferative activity after a brain injury.
    Neurochem Int.46(5):381-9, 2005 PubMed
  4. Kondo S, Murakami T, Tatsumi K,Ogata M, Kanemoto S, Otori K, Iseki K, Wanaka A, Imaizumi K
    OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.
    Nat Cell Biol.7(2):186-94, 2005 PubMed

2004年

  1. Mori T, Yuxing Z, Takaki H, Takeuchi M, Iseki K, Hagino S, Kitanaka J, Takemura M, Misawa H, Ikawa M, Okabe M, Wanaka A.
    The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons.
    Eur J Neurosci.19(12):3129-41, 2004  PubMed>
  2. Nonaka M, Yoshikawa M, Nishimura F, Yokota H, Kimura H, Hirabayashi H, Nakase H, Ishizaka S, Wanaka A, Sakaki T.
    Intraventricular transplantation of embryonic stem cell-derived neural stem cells in intracerebral hemorrhage rats.
    Neurol Res.26(3):265-72, 2004 PubMed

2003年

  1. Kanda S, Shiroi A, Ouji Y, Birumachi J, Ueda S, Fukui H, Tatsumi K, Ishizaka S, Takahashi Y, Yoshikawa M.
    In vitro differentiation of hepatocyte-like cells from embryonic stem cells promoted by gene transfer of hepatocyte nuclear factor 3 beta. 
    Hepatol Res. 26(3):225-231, 2003 PubMed>
  2. Hagino S, Iseki K, Mori T, Zhang Y, Sakai N, Yokoya S, Hikake T, Kikuchi S, Wanaka A.
    Expression pattern of glypican-1 mRNA after brain injury in mice.
    Neurosci Lett. 25;349(1):29-32, 2003  PubMed
  3. Shibaguchi T, Kato J, Abe M, Tamamura Y, Tabata MJ, Liu JG, Iwamoto M, Wakisaka S, Wanaka A, Kurisu K. Expression and role of Lhx8 in murine tooth development.
    Arch Histol Cytol. 66(1):95-108, 2003  PubMed
  4. Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A.
    Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.
    Anat Embryol (Berl)206(5):373-80, 2003  PubMed
  5. Zhang Y, Mori T, Iseki K, Hagino S, Takaki H, Takeuchi M, Hikake T, Tase C, Murakawa M, Yokoya S, Wanaka A.
    Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice.
    Dev Dyn. 226(4):618-26, 2003 PubMed
  6. Hagino S, Iseki K, Mori T, Zhang Y, Hikake T, Yokoya S, Takeuchi M, Hasimoto H, Kikuchi S, Wanaka A.
    Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain.
    Glia215;42(2):130-8, 2003  PubMed

2002年

  1. Shiroi A, Yoshikawa M, Yokota H, Fukui H, Ishizaka S, Tatsumi K, Takahashi Y. 
    Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone.
    Stem Cells 20(4):284-92, 2002  PubMed
  2. Nikaido T, Iseki K, Mori T, Takaki H, Yokoya S, Hagino S, Takeda J, Zhang Y, Takeuchi M, Kikuchi S, Wanaka A.
    Expression of OASIS, a CREB/ATF family transcription factor, in CNS lesion and its transcriptional activity.
    Brain Res Mol Brain Res.108(1-2):129-38, 2002 PubMed
  3. Iseki K, Hagino S, Mori T, Zhang Y, Yokoya S, Takaki H, Tase C, Murakawa M, Wanaka A.
    Increased syndecan expression by pleiotrophin and FGF receptor-expressing astrocytes in injured brain tissue.
    Glia 39(1):1-9, 2002 PubMed
  4. Zhang Y, Mori T, Takaki H, Takeuch M, Iseki K, Hagino S, Murakawa M, Yokoya S, Wanaka A.
    Comparison of the expression patterns of two LIM-homeodomain genes, Lhx6 and L3/Lhx8, in the developing palate.
    Orthod Craniofac Res.5(2):65-70, 2002  PubMed
大学院生募集

【連絡先】

奈良県立医科大学 
第2解剖学講座
(分子機能形態学講座)

〒634-8521
橿原市四条町840
tel/fax:0744-29-8825
address