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 2021-2011   2010-2006   2005-2001   2000-1989


2010

S. Miyake, H. Sakai, M. Takaori. Effects of crystalloid and colloid osmotic pressure on HbV (liposome encapsulated hemoglobin) membrane. Artif. Blood 18, 128-133 (2010).

S. Miyake, J. Takemura, H. Sakai, M. Takaori. Measurement of electrolyte concentrations in serum containing liposome vesicles. Artif. Blood 18, 91-95 (2010).

K. Taguchi, M. Miyasato, H. Ujihara, H. Watanabe, D. Kadowaki, H. Sakai, E. Tsuchida, H. Horinouchi, K. Kobayashi, T. Maruyama, M. Otagiri. Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment. Toxicol. Appl. Pharmacol. 248, 234-241 (2010, Nov.)

H. Sakai, N. Okuda, A. Sato, S. Takeoka, E. Tsuchida. Hemoglobin encapsulation in vesicles retards NO- and CO-bindings and O2-release when perfused through narrow gas-permeable tubes. Am. J. Physiol. Heart Circ. Physiol. 298, H956-H965 (2010, March)

H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida. Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure. Adv. Exp. Med. Biol. 662 (Oxygen Transport to Tissue XXXI) 433-438 (2010)

K. Yamamoto, H. Miyake, M. Kusunoki, S. Osaki.Crystal structure of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose, FEBS J. 277, 4205-4214 (2010)

酒井宏水、小松晃之、土田英俊、西出宏之. 臨床応用可能な酸素輸液の研究開発. 日経BPムック早稲田大学連携レビュー2010, 52-53 (2010)


2009

K. Taguchi, Y. Urata, M. Anraku, H. Watanabe, D. Kadowaki, H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida, T. Maruyama, M. Otagiri. Hemoglobin vesicles, polyethylene glycol (PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice. Drug Metab. Dispos. 37, 2197-2203 (2009, Nov.)

Y. Yamanashi, M. Mori, K. Terajima, T. Tsueshita, H. Horinouchi, H. Sakai, A. Sakamoto. A transient inflammatory reaction in the lung after experimental hemorrhagic shock and resuscitation with a hemoglobin-vesicles solution compared with rat RBC transfusion. ASAIO J. 55, 478-483 (2009, Sept-Oct).

J. A. Plock, N. Rafatmehr, D. Sinovcic, Y. Harder, H. Sakai, E. Tsuchida, A. Banic, D. Erni. Hemoglobin vesicles improve wound healing and tissue survival in critically ischemic murine skin. Am. J. Physiol. Heart Circ. Physiol. 297, H905-910 (2009, Spt).

H. Sakai, M. Okamoto, E. Ikeda, H. Horinouchi, K. Kobayashi, E. Tsuchida. Histopathological changes of rat brain after direct injection of hemoglobin-vesicles (oxygen carriers) and neurological impact in an intracerebral hemorrhage model. J. Biomed. Mater. Res. 90A, 1107-1119 (2009, Sept).

H. Sakai, A. Sato, S. Takeoka, E. Tsuchida. Mechanism of flocculate formation of highly concentrated phospholipid vesicles suspended in a series of water-soluble biopolymers. Biomacromolecules 10, 2344-2350 (2009, Aug).

H. Sakai, A. Sato, N. Okuda, S. Takeoka, N. Maeda, E. Tsuchida. Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube (25 mm). Am. J. Physiol. Heart Circ. Physiol. 297, H583-H589 (2009, Aug).

K. Taguchi, Y. Urata, M. Anraku, T. Maruyama, H. Watanabe, H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida, T. Kai, M. Otagiri. Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin-vesicles as an artificial oxygen carrier. Drug Metab. Dispos. 37, 1456-1463 (2009, July).

T. Sato, H. Sakai, K. Sou, O. Glatter, E. Tsuchida. Static structure and dynamics of hemoglobin vesicles (HbV) developed as a transfusion alternative. J. Phys. Chem. B. 113, 8418-8428 (2009, June).

K. Sou, R. Komine, H. Sakai, K. Kobayashi, E. Tsuchida, M. Murata. Clinical laboratory test of blood specimens containing hemoglobin-vesicles. -Interference avoidance by addition of dextran-. Artif. Blood 17, 6-15 (2009, June). 慶太郎、小峰 梨沙、酒井 宏水、小林 紘一、土田 英俊、村田 . ヘモグロビン小胞体を含有する血液検体の臨床検査. 人工血液 17, 6-15 (2009, 6).

K. Taguchi, T. Maruyama, Y. Iwao, H. Sakai, K. Kobayashi, H. Horinouchi, E. Tsuchida, T. Kai, M. Otagiri. Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model. J. Control. Release 136, 232-239 (2009, June).

M. Yamaguchi, M. Fujihara, S. Wakamoto, H. Sakai, S. Takeoka, E. Tsuchida, H. Hamada, H. Azuma, H. Ikeda. Effect of hemoglobin vesicles, cellular-type artificial oxygen carriers, on the ex vivo expansion of human hematopoietic stem/progenitor cells using a coculture system with human stromal cells. ASAIO J. 55, 200-205 (2009, May-June).

H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida. Hemoglobin-vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model. Shock 31, 507-514 (2009, May).

H. Sakai, Y. Seishi, Y. Obata, S. Takeoka, H. Horinouchi, E. Tsuchida, K. Kobayashi. Fluid resuscitation with artificial oxygen carriers in hemorrhaged rats: Profiles of Hb-vesicles degradation and hematopoiesis for 14 days. Shock 31, 192-200 (2009, Feb.).

M. Yamaguchi, M. Fujihara, S. Wakamoto, H. Sakai, S. Takeoka, E. Tsuchida, H. Azuma, H. Ikeda. Influence of hemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro. J. Biomed. Materials Res. A. 88A, 34-42 (2009, Feb.).

M. Yamamoto, Y. Izumi, H. Horinouchi, Y. Teramura, H. Sakai, M. Kohno, M. Watanabe, T. Adachi, E. Ikeda, S. Takeoka, E. Tsuchida, K. Kobayashi. Systemic administration of hemoglobin vesicles elevates tumor tissue oxygen tension and modifies tumor response to irradiation. J. Surg. Res. 151, 48-54 (2009, Jan).

H. Sakai, K. Sou, E. Tsuchida. Hemoglobin vesicles as a transfusion alternative. Methods Enzymol. 465 (Liposomes Part G) 363-384 (2009).

E. Tsuchida, K. Sou, A. Nakagawa, H. Sakai, T. Komatsu, K. Kobayashi. Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry. Bioconjugate Chem. 20(8) 1419-1440 (2009, Aug)

堀之内宏久、小林紘一、酒井宏水、土田英俊. 人工酸素運搬体. 「からだと酸素の事典」酸素ダイナミクス研究会 . 5:酸素の利用. pp.478-484, 20099, 朝倉書店, 東京. H. Horinouchi, K. Kobayashi, H. Sakai, E. Tsuchida. Artificial oxygen carriers. In: Encyclopedia of body and oxygen (Ed. by Oxygen Dynamics Society), Chapter 5, Utilization of Oxygen, pp478-484, Sept. 2009, Asakura Publishing Co., Ltd.,Tokyo.

H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida. Review of hemoglobin-vesicles as artificial oxygen carriers (Review paper). Artif. Organs 33, 139-145 (2009, Feb)

H. Sakai, E. Tsuchida. Past, present, and future of artificial red cells. Farumashia 45, 23-28 (2009). (in Japanese) 酒井宏水、土田英俊. 人工赤血球の過去、現在、未来. ファルマシア 45, 23-28 (2009, 1).

T. Matsuhira, H. Yamamoto, T. Okamura. Acidity control by on/off switching of an intramolecular NH...O hydrogen bond by E/Z photoisomerization of cinnamate framework, Chemistry Letters, 38, 666-667 (2009).
DOI: 10.1246/cl.2009.666


2008

H. Suzaki, H. Sakai, N. Kobayashi, T. Ikeda, H. Horinouchi, K. Kobayashi, S. Takeda, T. Togawa, E. Tsuchida. Study on Multiwavelength pulse spectrophotometry applicable for hemoglobin-vesilces. Artif. Blood 16, 198-204 (2008) (in Japanese). 須崎裕典、酒井宏水、小林直樹、池田達彦、堀之内宏久、小林 紘一、武田 朴、戸川 達男、土田英俊. 多波長パルス分光法を用いたHb小胞体用パルスオキシメータに関する研究. 人工血液 16, 198-204 (2008).

E.F. Verdu, P. Bercik, X.X. Huang, J. Lu, N. Al-Mutawaly, H. Sakai, T.A. Tompkins, K. Croitoru, E. Tsuchida, M. Prude, S.M. Collins. The role of luminal factors in the recovery of gastric functions and behavioral changes after chronic Helicobacter pylori infection. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G664-G670 (2008, Oct)

H. Sakai, A. Sato, P. Sobolewski, S. Takeoka, J.A. Frangos, K. Kobayashi, M. Intaglietta, E. Tsuchida. NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers. Biochim. Biophys. Acta (Proteins and Proteomics) 1784, 1441-1447 (2008, Oct.).

F. Ma, Y. Ebihara, K. Umeda, H. Sakai, S. Hanada, H. Zhang, Y. Zaike, E Tsuchida, T. Nakahata, H. Nakauchi, K. Tsuji. Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis. Proc. Natl. Acad. Sci. USA. 105, 13087-13092 (2008, Sept)

A. Fujimi, T. Matsunaga, M. Kobune, Y. Kawano, T. Nagaya, I. Tanaka, S. Iyama, T. Hayashi, T. Sato, K. Miyanishi, T. Sagawa, Y. Sato, R. Takimoto, T. Takayama, J. Kato, S. Gasa, H. Sakai, E. Tsuchida, K. Ikebuchi, H. Hamada, Y. Niitsu. Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages. Int. J. Hematol. 87, 339-350 (2008, May).

H. Sakai, A. Sato, K. Masuda, S. Takeoka, E. Tsuchida. Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier. J. Biol. Chem. 283, 1508-1517 (2008, Jan).

H. Sakai, H. Horinouchi, K. Kobayashi. Report on FDA Workshop on Hemoglobin Based Oxygen Carriers. Artif. Blood 16, 23-29 (2008). (in Japanese) 酒井宏水、堀之内宏久、小林紘一. FDA Workshop on Hemoglobin Based Oxygen Carriersに参加して. 人工血液 16, 23-29 (2008).

H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida. Hemoglobin-vesicles as artificial oxygen carriers: Present situation and future vision. J. Intern. Med. 263, 4-15 (2008).

K. Yamamoto, H. Miyake, M. Kusunoki, S. Osaki, Crystallization and preliminary X-ray analysis of isomaltase from Saccharomyces cerevisiae. Acta Crystallogr. Sect. F 64, 1024-1026 (2008).

T. Matsuhira, H. Yamamoto, K. Tsuchihashi, T. Okamura, N. Ueyama. Novel photosystem involving protonation and deprotonation process modeled on PYP photocycle, Organic & Biomolecular Chemistry, 6, 3118-3126 (2008).
DOI: 10.1039/b807417h

T. Matsuhira, H. Yamamoto, T. Okamura, N. Ueyama. Manipulation of an intramolecular NH...O hydrogen bond by photoswitching between stable E/Z isomers of the cinnamate framework, Organic & Biomolecular Chemistry, 6, 1926-1933 (2008).
DOI: 10.1039/b719960k


2007

A. Sato, H. Sakai, S. Takeoka, E. Tsuchida. Rheological properties of hemoglobin-vesicles (artificial red cells) suspended in a series of plasma-substitute solutions and their mixtures with blood. Hemorheol. Related Res. 10, 3-11 (2007) (in Japanese). 佐藤 敦、酒井 宏水、武岡 真司、土田 英俊. 各種代用血漿剤に分散させたヘモグロビン小胞体(人工赤血球)とその血液混合系のレオロジー特性. 日本ヘモレオロジー学会誌 10, 3-11 (2007).

H. Sakai, A. Sato, S. Takeoka, E. Tsuchida. Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma substitute solutions. Langmuir 23, 8121-8128 (2007, July).

H. Abe, H. Azuma, M. Yamaguchi, M. Fujihara, H. Ikeda, H. Sakai, S. Takeoka, E. Tsuchida. Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactic reactions in rats. Artif. Cells Blood Substitutes Biotechnol. 35, 157-172 (2007, April).

H. Sakai, H. Horinouchi, E. Tsuchida, K. Kobayashi. One-year observation of Wistar rats after infusion of Hb-vesicles (Artificial oxygen carriers). Artif. Cells Blood Substitutes Biotechnol. 35, 81-91 (2007, March).

J. Plock, A. E. Tromp, C. Contaldo, T. Spanholtz, D. Sinovcic, H. Sakai, E. Tsuchida, M. Leunig, A. Banic, D. Erni, Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue. Crit Care Med. 35, 899-905 (2007, March).

T. Sato, H. Sakai, K. Sou, E. Tsuchida. Molecular to cooperative dynamics and static structures of PEG-conjugated phospholipid in aqueous micellar solutions: dielectric spectroscopy and SAXS study. J. Phys. Chem. B. 111, 1393-1401 (2007, Feb).

H. Sakai, K. Sou, E. Tsuchida. Solution to the problems of acellular Hbs by encapsulation, and the intrinsic issues of Hb-vesicles as a molecular assembly. Transfusion Alternatives in Transfusion Medicine 9, 226-236 (2007).

D. Erni, R. Wettstein, C. Contaldo, J. Plock, N. Rafatmehr, H. Sakai, E. Tsuchida. Hemoglobin vesicles to treat hypoxia in critically ischemic tissue. 人工血液(Artif. Blood) 15, 58-64 (2007).

H. Sakai, E. Tsuchida. Oxygen infusion as a transfusion alternative and its utilization in tissure regeneration. Environment and Health 20, 464-472 (2007) (in Japanese). 酒井宏水、土田英俊. 輸血の代替が可能な酸素輸液の実現と 組織再生技術. 環境と健康 20, 464-472 (2007)

H. Sakai, E. Tsuchida. Hemoglobin-vesicles for a Transfusion Alternative and Targeted Oxygen Delivery. J. Liposome Res. 17, 227- 235 (2007).

H. Sakai, H. Horinouchi, M. Yamamoto, E. Ikeda, S. Takeoka, M. Takaori, E. Tsuchida, K. Kobayashi. Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks (Secondary Publication). Jpn J. Transfusion Cell Therap. 53, 47-55 (2007) (in Japanese). 酒井宏水、堀之内宏久、山本学、池田 栄二、武岡真司、高折益彦、土田英俊、小林紘一 / ヘモグロビン小胞体(HbV)-リコンビナントアルブミン分散溶液による40%交換輸血:ラット脾臓内HbV代謝と造血に関する2週間の観察 (論文記事: secondary publication). 日本輸血細胞治療学会誌 53, 47-55 (2007).


2006

Y. Goto, K. Terajima, T. Tsueshita, M. Miyashita, H. Horinouchi, H. Sakai, E. Tsuchida, A. Sakamoto. Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock. Biomed. Res. 27, 283-288 (2006).

T. Atoji, M. Aihara, H. Sakai, E. Tsuchida, S. Takeoka. Hemoglobin vesicles containing methemoglobin and L-tyrosine to suppress methemoglobin formation in vitro and in vivo. Bioconjugate Chem. 17, 1241-1245 (Sept.-Oct., 2006).

H. Sakai, H. Horinouchi, M. Yamamoto, E. Ikeda, S. Takeoka, M. Takaori, E. Tsuchida, K. Kobayashi. Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks. Transfusion 46, 339-347 (2006, March).

H. Sakai, P. Cabrales, A.G. Tsai, M. Intaglietta, E. Tsuchida. Oxygen Release from low and normal P50 Hb-vesicles in Transiently Occluded Arterioles of the Hamster Window Model (Secondary Publication). Artif. Blood 14, 130-137 (2006) (in Japanese). 酒井宏水、ペドロカブラレス、エミ G. ツァイ、土田英俊、マルコスインタリエッタ. ハムスター皮下の細動脈血流を一過性に遮断するモデルを用いたP50値が異なるHb小胞体の酸素放出挙動. (二次掲載) 人工血液 14, 130-137 (2006).

H. Sakai, E. Tsuchida. “Blood Substitutes”, In: Wiley Encyclopedia of Biomedical Engineering. M. Akay (Ed.), pp. 613-621, 2006, John Wiley & Sons, Inc., Hoboken, NJ.

E. Tsuchida, H. Sakai, H. Horinouchi, K. Kobayashi. Hemoglobin-vesicles as a transfusion alternative. Artif. Cells Blood Substitutes Biotechnol. 34, 581-588 (2006).

H. Sakai, E. Tsuchida. Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation. Clin. Hemorheol. Microcirc. 34, 335-340 (2006)

A.G. Tsai, P. Cabrales, H. Sakai, and M. Intaglietta. “Blood Substitutes' Efficacy: Microvascular and Theological Determinants.” In: Microvascular Research: Biology and Pathology, Vol. 2. (Ed: David Shepro), San Diego: Elsevier, pp. 1095-1103 (2006).

H. Sakai, K. Sou, S. Takeoka, K. Kobayashi, and E. Tsuchida, “Hemoglobin-Vesicles as a Molecular Assembly: Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers.” In “Blood Substitutes” (Ed. By Robert M. Winslow, Elsevier) Chapt. 44, pp. 514-522, 2006.

T. Matsuhira, H. Yamamoto, A. Onoda, T. Okamura, N. Ueyama. Photoinduced switching of intramolecular hydrogen bond between amide NH and carboxyl oxygen. Organic & Biomolecular Chemistry, 4, 1338-1342 (2006).
DOI:10.1039/B516049A


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