Updated : August 1, 2023

Department of Embryology

Members

Kazuki Kurimoto (Professor)
Hisato Kobayashi (Associate professor)
Hiroki Ikeda (Assistant professor) 
So Nagaoka (Assistant professor)

Research

All cells in our body originate from a single fertilized egg and possess essentially the same genomic information. However, during ontogenesis (the development of the body), diverse cell types arise from the fertilized egg. Among these, germ cells (sperm and eggs) hold a unique role as they have the ability to transmit genomic information and developmental potential to the next generation. Throughout individual and germ cell development, the genome undergoes intricate regulation through complex processes, the precise mechanisms of which remain largely unknown.

In our research, we aim to investigate the mechanisms underlying genomic regulation during germline development. To achieve this, we have developed analytical methods for studying the transcriptome and epigenome in small cell populations, including single cells in contexts in living organs. This is because development often involves critical roles played by a small number of cells. Through our investigations, we strive to enhance our understanding of how developmental potential takes shape in germ cells and how our hereditary information is passed down from our parents and will be transmitted to future generations. By shedding light on these fundamental processes, our research contributes to the broader knowledge of developmental biology and genetics.

Our website is here