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Updated : January 14, 2016

Department of Blood Transfusion Medicine (Bloodstream Reconstructive Medicine)


Masanori Matsumoto
Masaki Hayakawa


We aim to conduct research that will directly contribute to clinical services. For example, since 1998, we have diagnosed more than 1,000 patients with thrombotic microangiopathy (TMA) through analysis of ADAMTS13 at the request of medical institutions throughout Japan. Based on our experience of analyzing such an unprecedentedly large number of TMA patients, we have performed pathological analysis of thrombotic thrombocytopenic purpura (TTP) and examined phenotype-genotype relationships in Upshaw-Schulman syndrome as congenital TTP. At present, we are actively addressing the following research themes: pathological analysis of TMA as a fatal complication of hematopoietic stem cell transplantation; the establishment of methods of comprehensive diagnosis, including genetic analysis of von Willebrand disease which has rarely been performed in Japan; and pathological analysis of Heyde’s syndrome associated with acquired von Willebrand syndrome which is recently drawing attention in Japan.


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