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 2019-2011   2010-2006   2005-2001   2000-1989


2019

H. Sakai, C. Leong, Prolonged functional life span of artificial red cells in blood circulation by repeated methylene blue injections. Artif. Cells Nanomed. Biotechnol. 47(1), 3123-3128 (2019). DOI:10.1080/21691401.2019.1645157

K. Hagisawa, M. Kinoshita, M. Takikawa, S. Takeoka, D. Saitoh, S. Seki, H. Sakai, Combination therapy using fibrinogen γ‐chain peptide‐coated, ADP‐encapsulated liposomes and hemoglobin vesicles for trauma‐induced massive hemorrhage in thrombocytopenic rabbits. Transfusion (in press). DOI:10.1111/trf.15427

M. Yamada, T. Matsuhira, K. Yamamoto, H. Sakai, Antioxidative pseudo-enzymatic mechanism of NAD(P)H coexisting with oxyhemoglobin for suppressed methemoglobin formation. Biochemistry 58(10), 1400-1410 (2019). DOI:10.1021/acs.biochem.8b01314

T. Matsuhira, K. Yamamoto, H. Sakai, Ring-opening polymerization of hemoglobin. Biomacromolecules 20(4), 1592-1602 (2019). DOI:10.1021/acs.biomac.8b01789

B. Takase, Y. Higashimura, K. Hashimoto, H. Asahina, M. Ishihara, H. Sakai, Myocardial Electrical Remodeling and the Arrhythmogenic Substrate in Hemorrhagic Shock-Induced Heart: Anti-Arrhythmogenic Effect of Liposome-Encapsulated Hemoglobin (HbV) on the Myocardium. Shock 52(3), 378-386 (2019). DOI: 10.1097/SHK.0000000000001262


2018

T. Matsuhira, T. Kure, K. Yamamoto, H. Sakai, Analysis of dimeric αβ subunit exchange between PEGylated and native hemoglobins (α2β2 tetramer) in an equilibrated state by intramolecular ββ-crosslinking. Biomacromolecules 19(8), 3412-3420 (2018). DOI: 10.1021/acs.biomac.8b00728

H. Sengyoku, T. Tsuchiya, T. Obata, R. Doi, Y. Hashimoto, M. Ishii, H. Sakai, N. Matsuo, D. Taniguchi, T. Suematsu, M. Lawn, K. Matsumoto, T. Miyazaki, T Nagayasu, Sodium hydroxide based non-detergent decellularizing solution for rat lung. Organogenesis 14(2), 94-106 (2018). DOI: 10.1080/15476278.2018.1462432

K. Taguchi, S. Nagao, H. Maeda, H. Yanagisawa, H. Sakai, K. Yamasaki, T. Wakayama, H. Watanabe, M. Otagiri, T. Maruyama, Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity. Drug Delivery 25(1), 1266-1274 (2018). DOI: 10.1080/10717544.2018.1477860

N. Rikihisa, M. Tomonaga, S. Watanabe, Y. Saito, H. Sakai, Intravenous injection of artificial red cells and subsequent dye laser irradiation causes deep vessel impairment in an animal model of port-wine stain. Lasers Med. Sci. 33(6), 1287-1293 (2018). DOI: 10.1007/s10103-018-2480-2

T. Shonaka, N. Matsuno, H. Obara, R. Yoshikawa, Y. Nishikawa, M. Gouchi, M. Otani, H. Takahashi, H. Azuma, H. Sakai, H. Furukawa, The application of perfusate with human-derived oxygen carrier solution under subnormothermic machine perfusion for donation after cardiac death (DCD) liver grafts in pigs. Transp. Proc. 50(9), 2821-2825 (2018). DOI: 10.1016/j.transproceed.2018.02.184

K. Hagisawa, M. Kinoshita, B. Takase, K. Hashimoto, D. Saitoh, S. Seki, Y. Nishida, H. Sakai, Efficacy of Resuscitative Transfusion with Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits with Thrombocytopenic Coagulopathy and its Effect on Hemostasis by Platelet Transfusion. Shock 50(3), 324-330 (2018). DOI: 10.1097/SHK.0000000000001042

庄中達也,松野直徒,小原弘道,吉川遼,西川祐司,合地美香子,大谷将秀,高橋裕之,東寛,酒井宏水,古川博之. 心停止ドナーへの肝移植に対する人工赤血球(Hemoglobin vesicles, HbV)を用いた灌流保存方法の有効性. 北海道外科雑誌 63(2), 46-48 (2018).

酒井宏水奥田千愛久禮智子. 人工赤血球の開発と臨床応用. LiSA 25(11), 1139-1146 (2018).

酒井宏水. 輸血代替の他にもさまざまな利用が期待される「人工赤血球」とは. Medical Technology 46 (9), 832-834 (2018).

H. Sakai, Artificial red cells (hemoglobin vesicles) as a transfusion alternative and their new clinical applications. Japanese Journal of Transfusion and Cell Therapyt 64(4), 589-596 (2018). (in Japanese) 酒井宏水. 人工赤血球(ヘモグロビン ベシクル)製剤の新しい利用法. 日本輸血細胞治療学会雑誌 64(4), 589-596 (2018).

T. Kure, H. Sakai, The measurement of the lipid membrane fluidity of liposomes encapsulating a concentrated protein solution using a fluorescence polarization technique. Jasco report 60(2), 5-12 (2018). (in Japanese) 久禮智子酒井宏水. 蛍光偏光解消法による高濃度蛋白質溶液を内包したリポソーム脂質膜の流動性評価. Jasco Report 60(2), 5-12 (2018).

酒井宏水. 廃棄する血液から人工赤血球をつくる。長期保存可能、献血不足の課題解決に. コンバーテック 541, 20-23 (2018).

酒井宏水,太田英伸,小林紘一,八重樫伸生. 人工赤血球(ヘモグロビンベシクル). 日本産婦人科医会、研修ノートNo. 100「産婦人科医療の近未来」 67-69 (2018年 1月).


2017

S. Ghirmai, L. Bulow, H. Sakai, In vivo evaluation of electron mediators for the reduction of methemoglobin encapsulated in liposomes using electron energies produced by red blood cell glycolysis. Artif. Cells Nanomed. Biotechnol. 46, 1364-1372 (2017). DOI: 10.1080/21691401.2017.1397003

H. Ohta, M. Kaga, H. Li, H. Sakai, K. Okamura, N. Yaegashi, Potential New Non-Invasive Therapy Using Artificial Oxygen Carriers for Pre-Eclampsia. J. Funct. Biomater. 8, 32 (2017). DOI: 10.3390/jfb8030032

H. Azuma, M. Fujihara, H. Sakai, Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function. J. Funct. Biomater. 8, 24 (2017). DOI: 10.3390/jfb8030024

M. Kohno, T. Ikeda, R. Hashimoto, Y. Izumi, M. Watanabe, H. Horinouchi, H. Sakai, K. Kobayashi, M. Iwazaki, Acute 40% exchange-transfusion with hemoglobin-vesicles in a mouse pneumonectomy model. PLOS ONE 12(6), e0179724 (2017). DOI: 10.1371/journal.pone.0178724

M. Yamada, H. Sakai. Hidden Antioxidative Functions of NADH Coexisting with Hemoglobin. ACS Chem. Biol. 12(7), 1820-1829 (2017). DOI: 10.1021/acschembio.7b00174

K. Taguchi, K. Yamasaki, H. Sakai, T. Maruyama, M. Otagiri, The use of Hemoglobin-vesicles for delivering medicinal gas for the treatment of intractable disorders. J. Pharmaceut. Sci. 106(9), 2392-2400 (2017). DOI: 10.1016/j.xphs.2017.04.006

H. Azuma, Y, Yoshida, H. Takahashi, E. Ishibazawa, H. Kobayashi, H. Sakai, D. Takahashi, M. Fujihara. Liposomal microparticle injection can induce myeloid-derived suppressor cells (MDSC)-like cells in vivo. Immunopharmacol. Immunotoxicol. 39, 140-147 (2017). DOI: 10.1080/08923973.2017.1306867

N. Rikihisa, S. Watanabe, Y. Saito, H. Sakai. Artificial Red Blood Cells as Potential Photosensitizers in Dye Laser Treatment Against Port-Wine Stains. J. Funct. Biomater. 8, 14, (2017). DOI: 10.3390/jfb8020014

H. Sakai. Overview of potential clinical applications of hemoglobin vesicles (HbV) as artificial red cells, evidenced by preclinical studies of the academic research consortium. J. Funct. Biomater. 8, 10 (2017). DOI: 10.3390/jfb8010010

Y. Naito, H. Sakai, S. Inoue, M. Kawaguchi. Hemoglobin vesicles prolong the time to circulatory collapse in rats during apnea. BMC Anesthesiol. 17, 44 (2017). DOI: 10.1186/s12871-017-0338-y

N. Rikihisa, S. Watanabe, K. Satoh, Y. Saito, H. Sakai. Photosensitizer Effects of Artificial Red Cells on Dye Laser Irradiation in an Animal Model Assuming Port-Wine Stain Treatment. Plast. Reconstr. Surg. 139, 707e-716e (2017). DOI: 10.1097/PRS.0000000000003082

T. Kure, H. Sakai. Transmembrane difference in colloid osmotic pressure affects the lipid membrane fluidity of liposomes encapsulating a concentrated hemoglobin solution. Langmuir 33, 1533-1540 (2017). DOI: 10.1021/acs.langmuir.6b04643


2016

M. Tokuno, K. Taguchi, K. Yamasaki, H. Sakai, M. Otagiri. Long-term stored hemoglobin-vesicles, a cellular type of hemoglobin-based oxygen carrier, has resuscitative effects comparable to that for fresh red blood cells in a rat model with massive hemorrhage without post-transfusion lung injury. PLoS ONE 11(10), e0165557 (2016).

S. Nagao, K. Taguchi, H. Sakai, K. Yamasaki, H. Watanabe, M. Otagiri, T. Maruyama. Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties. Int. J. Nanomedicine 11, 5611-5620 (2016).

S. Nagao, K. Taguchi, Y. Miyazaki, T. Wakayama T, VT. Chuang, K. Yamasaki, H. Watanabe, H. Sakai, M. Otagiri, T. Maruyama. Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis. J. Control. Release 234, 49-58 (2016).

S. Osaki, K. Yamamoto, T. Matsuhira, H. Sakai. The effects of seasonal changes on the molecular weight of Nephila clavata spider silk. Polymer Journal 48, 659-653 (2016). DOI: 10.1038/pj.2015.138

酒井宏水(翻訳分担). ハーバー・生化学(原書30版)2016/11/30 丸善 53(799-811) 清水孝雄(監訳).

太田英伸,加賀麻衣子,李コウ,酒井宏水,岡村州博,八重樫伸生. 人工酸素運搬体は妊娠高血圧症候群ラットモデルの胎盤低酸素・胎仔発育不全を治療する. 人工血液 24, 63-72 (2016).


2015

B. Namgung, H. Sakai, S. Kim. Influence of erythrocyte aggregation at pathological levels on cell-free marginal layer in a narrow circular tube. Clin. Hemorheol. Microcirculation 61, 445-457 (2015).

H. Li, H. Ohta, Y. Tahara, S. Nakamura, K. Taguchi, M. Nakagawa, Y. Oishi, Y. Goto, K. Wada, M. Kaga, M. Inagaki, M. Otagiri, H. Yokota, S. Shibata, H. Sakai, K. Okamura, N. Yaegashi. Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model. Sci. Rep. 5, 15271 (2015).

K. Taguchi, S. Nagao, K. Yamasaki, H. Sakai, H. Seo, T. Maruyama, M. Otagiri. Biological Responsiveness and Metabolic Performance of Liposome-Encapsulated Hemoglobin (Hemoglobin-Vesicles) in Apolipoprotein E-Deficient Mice after Massive Intravenous Injection. Biol. Pharm. Bull. 38, 1606-1616 (2015).

K. Kettisen, L. Bulow, H. Sakai. Potential electron mediators to extract electron energies of RBC glycolysis for prolonged in vivo functional lifetime of hemoglobin-vesicles. Bioconjugate Chem. 26, 746-754 (2015).

J. Araki, H. Sakai, D. Takeuchi, Y. Kagaya, M. Naito, M. Mihara, M. Narushima, T. Iida, I. Koshima. Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles. Transplantation 99, 687-692 (2015).

T. Matsuhira, S. Osaki. Molecular weight of Nephila clavata spider silk. Polymer Journal, 47, 456-459 (2015). DOI: 10.1038/pj.2015.10

酒井宏水, 久禮智子. 人工赤血球(ヘモグロビンベシクル)の実現に向けて. 医学のあゆみ 253, 1180-1181 (2015).


2014

H. Sakai, B. Li, W. Lim, Y. Iga. Red blood cells donate electrons to methylene blue mediated chemical reduction of methemoglobin compartmentalized in liposome in blood. Bioconjugate Chem. 25, 1301-1310 (2014).

S. Nagao, K. Taguchi, H. Sakai, R. Tanaka, H. Horinouchi, H. Watanabe, K. Kobayashi, M. Otagiri, T. Maruyama. Carbon monoxide-bound hemoglobin-vesicles as a potential therapeutic agent for the treatment of bleomycin-induced pulmonary fibrosis. Biomaterials 35, 6553-6562 (2014).

M. Fujihara, D. Takahashi, H. Abe, H. Sakai, H. Horinouchi, K. Kobayashi, H. Ikeda, H. Azuma. Primary and secondary immune responses to keyhole limpet hemocyanin in rats after the infusion of hemoglobin vesicle, an artificial oxygen carrier. Artif. Organs 38, 234-238 (2014) .

酒井宏水, 人工赤血球(ヘモグロビン小胞体)微粒子分散液の特徴. 粉体工学 6, 909-914 (2014).

酒井宏水, 人工赤血球による生体組織への酸素輸送. 「全人力・科学力・透析力に基づく透析医学」第6章: 腎性貧血. pp.369-373、平方秀樹 監修、医薬ジャーナル社. 大阪 (2014).

酒井宏水, 人工赤血球の開発状況と将来展望. Anesthesia Network 18, 37-41 (2014).


2013

H. Sakai, K. Ng, B. Li, N. Sugimura. Swine hemoglobin as a potential source of artificial oxygen carriers, hemoglobin-vesicles. Artif. Cells Nanomed. Biotechnol. 41, 37-41 (2013).

H.W. Kim, J.S. Jahr, A. Mozzarelli, H. Sakai. International consortium for development of hemoglobin-based oxygen carriers, oxygen therapeutics and multifunctional resuscitation fluids-a white paper. In: Hemoglobin-based oxygen carriers-principles, approaches and current status (H.W. Kim & A.G. Greenburg eds.) Springer-Verlag (Berlin/Heidelberg, Germany). Chapter 39, pp. 737-746 (2013).

T. Ikeda, H. Horinouchi, H. Sakai. Cellular-type hemoglobin-based oxygen carriers as a resuscitative fluid for hemorrhagic shock: acute and long-term safety evaluation using beagle dogs. In: Hemoglobin-based oxygen carriers-principles, approaches and current status (H.W. Kim & A.G. Greenburg eds.) Springer-Verlag (Berlin/Heidelberg, Germany). Chapter 28, pp. 501-526 (2013).

H. Azuma, M. Fujihara, H. Sakai. Biocompatibility of hemoglobin vesicles, a cellular-type artificial oxygen carrier, on blood cells and plasma proteins in vitro and in vivo. In: Hemoglobin-based oxygen carriers-principles, approaches and current status (H.W. Kim & A.G. Greenburg eds.) Springer-Verlag (Berlin/Heidelberg, Germany). Chapter 22, pp. 385-398 (2013).

H. Sakai. Cellular-type hemoglobin-based oxygen carriers to mimic the red blood cells structure. In: Hemoglobin-based oxygen carriers-principles, approaches and current status (H.W. Kim & A.G. Greenburg eds.) Springer-Verlag (Berlin/Heidelberg, Germany). Chapter 12, pp. 235-248 (2013).

酒井宏水,堀之内宏久、東寛、小田切優樹、小林紘一. 輸血代替としての人工赤血球(ヘモグロビン小胞体)製剤の安全性試験. 人工血液 21, 36-48 (2013).

H. Sakai. Biocompatibility of a highly concentrated fluid of Hemoglobin-vesicles as a transfusion alternative. In: Selective Topics in Nanomedicine (T.M.S. Chang ed.), pp. 133-147, World Scientific, Singapore (2013).

T. Matsuhira, K. Yamamoto, S. Osaki. Effects of UV irradiation on the molecular weight of spider silk, Polymer Journal, 45, 1167-1169 (2013). DOI: 10.1038/pj.2013.41


2012

K. Taguchi, H. Watanabe, H. Sakai, H. Horinouchi, K. Kobayashi, T. Maruyama, M. Otagiri. Fourteen-days observation and pharmacokinetic evaluation after massive intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers) in cynomolgus monkeys. J. Drug Metab. Toxicol. 3, 1000128 (2012).

M. Kaga, H. Ohta, Y. Lee, R. Kamii, H. Yamamoto, S. Akiyama, S. Watanabe, T. Matsuda, Y. Kimura, S. Tsuchiya, H. Tei, L. Okamura, H. Sakai, N. Yaegashi. Physiolgical capacity of the reticuloendothelial system for the degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusion for 7 days in Pregnant rats and fetuses. Life Sci. 91, 420-428 (2012).

H. Sakai, Y. Suzuki, K. Sou, M. Kano. Cardiopulmonary hemodynamic responses to the small injection of hemoglobin-vesicles (artificial oxygen carriers) in miniature pigs. J. Biomed. Mater. Res. A, 100A, 2668-2677 (2012).

A.G. Tsai, M. Intaglietta, H. Sakai, E. Delpy, C.D. la Rochelle, M. Rousselot, F. Zal. Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier. Current Drug Discovery Techonl. 9, 166-172 (2012).

Y. Seishi, H. Horinouchi, H. Sakai, K. Kobayashi. Effect of the cellular-type artificial oxygen carrier Hb-vesicle as a resuscitative fluid for pre-hospital treatment: Experiments in a rat uncontrolled hemorrhagic shock model. Shock 38, 153-158 (2012).

H. Sakai, K. Sou, H. Horinouchi, E. Tsuchida, K. Kobayashi. Removal of Hemoglobin-vesicles from circulating blood by using centrifugation and ultrafiltration. Artif. Organs 36, 202-209 (2012).

M. Yamamoto, H. Horinouchi, Y. Seishi, N. Sato, M. Itoh, K. Kobayashi, H. Sakai, Fluid resuscitation of hemorrhagic shock with Hemoglobin vesicles in Beagle dogs: pilot study. Artif. Cells Blood Substitutes Biotechnol. 40, 179-195 (2012).

T. Sato, T. Fukasawa, T. Komatsu, H. Sakai, S. Ishiwata. Protein-protein interactions in solution and their interplay with protein specific functions. J. Phys. Soc. Jpn 81 (suppl.), SA002-1 - SA-002-11 (2012).

H. Sakai. Cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics. Current Drug Discovery Techonl. 9, 188-193 (2012).


2011

H. Sakai, N. Miyagawa, H. Horinouchi, S. Takeoka, M. Takaori, E. Tsuchida, K. Kobayashi. Intravenous injection of Hb-vesicles (artificial oxygen carriers) after hemodilution with a series of plasma expanders (water-soluble biopolymers) in a rat repeated hemorrhage model. Polymers Adv. Technol. 22, 1216-1222 (2011).

A. Niwa, T. Heike, K. Umeda, K. Oshima, I. Kato, H. Sakai, H. Suemori, T. Nakahata, M.K. Saito. A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors". PLoS ONE 6, e22261 (2011).

K. Taguchi, S. Ogaki, H. Watanabe, D. Kadowaki, H. Sakai, K. Kobayashi, H. Horinouchi, T. Maruyama, M. Otagiri. Fluid resuscitation with hemoglobin vesicles prevents Esherichia coli growth via complement activation in a hemorrhagic shock rat model. J. Pharmacol. Exp. Therap. 337, 201-208 (2011).

D. Takahashi, H. Azuma, H. Sakai, K. Sou, D. Wakita, H. Abe, M. Fujihara, H. Horinouchi, K. Kobayashi, T. Nishimura, H. Ikeda. Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture condition. J. Pharmacol. Exp. Therap. 337, 42-49 (2011).

K. Taguchi, Y. Iwao, H. Watanabe, D. Kadowaki, H. Sakai, K. Kobayashi, H. Horinouchi, T. Maruyama, M. Otagiri. Repeated injection of high dose of hemoglobin encapsulated liposomes (hemoglobin-vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model. Drug Metab. Dispos. 39, 484-489 (2011).

H. Sakai, N. Okuda, S. Takeoka, E. Tsuchida. Increased viscosity of hemoglobin-based oxygen carriers retards NO-binding when perfused through narrow gas-permeable tubes. Microvasc. Res. 81, 169-176 (2011).

K. Taguchi, M. Miyasato, H. Watanabe, H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida, T. Maruyama, M. Otagiri. Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity. J. Pharmaceut. Sci. 100, 775-783 (2011).

P.K. Ong, S. Jain, B. Namgung, Y.I. Woo, H. Sakai, D. Lim, K.J. Chun, S. Kim. An automated method for cell-free layer width determination in small arterioles. Physiol. Meas. 2011, 32, N1-N12 (2011).

H. Sakai, S. Takeoka, K. Kobayashi. Gas bioengineering using hemoglobin-vesicles for versatile clinical application. Current Pharmaceutical Design 17, 2352-2359 (2011).

H. Sakai. What is the major mechanism of slower NO uptake by red blood cells? (Letter to Editorial). J. Biol. Chem. 286, le22, (2011).

H.W. Kim, A. Mozzarelli, H. Sakai, J. Jahr. Academia-industry collaboration in blood substitute development. -issues, case histories and a proposal. In: Chemistry and Biochemistry of Oxygen Therapeutics: from Transfusion to Artificial Blood. (Ed. by S. Bettati and A. Mozzarelli), Chapter 29. pp. 413-428. John Wiley & Sons (2011).

H. Sakai, H. Horinouchi, E. Tsuchida, K. Kobayashi. Hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier. In: Chemistry and Biochemistry of Oxygen Therapeutics: from Transfusion to Artificial Blood. (Ed. by S. Bettati and A. Mozzarelli), Chapter 27, pp.381-390. John Wiley & Sons (2011).

H. Sakai. Artificial oxygen carriers (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics. IFMBE Proceedings 35 (5th Kuala Lumpur International Conference on Biomedical Engineering 2011 (BIOMED 2011) 20-23 June 11, Kuala Lumpur, Malaysia), 845-848 (2011).

K. Yamamoto, H. Miyake, M. Kusunoki, S. Osaki, Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae, J. Biosci. Bioeng., 112, 545-550 (2011).


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