Updated : October 7, 2020

Biofunctional Control Mechanisms

Supervisor

Kyoji Horie (Professor)

Specialized Subjects

Students will learn about general approaches to examine diverse biological phenomena from the perspectives of molecular biology, cell biology, and genome science. As an experimental system, we will focus on the differentiation of ES cells into various cell lineages and generation of iPS cells by reprogramming somatic cells, with a view to developing an understanding of gene networks controlling these phenomena.
Goals for students:
1. Learning about basic items related to the genomic structure and gene expression.
2. Developing skills to utilize various databases related to the genome and gene expression, in order to extract information necessary for each experiment.
3. Mastering basic techniques related to ES/iPS cell culture, ES cell differentiation, and somatic cell reprogramming to create iPS cells.
4. Integrating knowledge of these items to master techniques for forced gene expression or disruption within the cell.
5. Learning methods to quantify the effects of genetic modification.