Updated : August 25, 2023

Department of Blood Transfusion Medicine

Members

Masanori Matsumoto
Kazuya Sakai
Masayuki Kubo

Overview

We aim to conduct research that will directly contribute to clinical services. For example, since 1998, we have diagnosed more than 1,600 patients with thrombotic microangiopathy (TMA) through analysis of ADAMTS13 at the request of medical institutions throughout Japan. Based on our experience of analyzing such an unprecedentedly large number of TMA patients, we have performed pathological analysis of thrombotic thrombocytopenic purpura (TTP) and examined phenotype-genotype relationships in Upshaw-Schulman syndrome as congenital TTP. At present, we are actively addressing the following research themes: pathological analysis of TMA as a fatal complication of hematopoietic stem cell transplantation; the establishment of methods of comprehensive diagnosis, including genetic analysis of von Willebrand disease which has rarely been performed in Japan; and pathological analysis of Heyde’s syndrome associated with acquired von Willebrand syndrome which is recently drawing attention in Japan.

Website

Our website is here( External link )