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Updated : August 7, 2020

Department of Obstetrics and Gynecology(Bioregulatory Medicine of Female Genital Organs)

Teacher and Staff

Ryuji Kawaguchi
Seji Mabuchi
Katsuhiko Naruse


We have focused on the pathophysiologic roles of oxidative stress as somatic mutations as well as highly specific agents that effectively modulate the therapeutic targets in endometriosis and its malignant transformation. Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression of ARID1A, PIK3CA, and NF-kB genes has been recognized as the major target genes involved in oxidative stress-induced carcinogenesis. Transcription factor HNF-1beta also appears to play a key role in anti-oxidative defense mechanisms.
In the field of perinatal medicine, as the single perinatal emergency center of the prefecture (10,500 prefectural birth per year), we are well known as a specialist in the basic / clinical research of obstetrical emergency like hypertensive pregnancy, amniotic fluid embolism, threatened premature labor and postpartum hemorrhage. Our previous studies were focused on early placentation and separated invasive trophoblast, pathophysiology of the obstetrical emergency condition including inflammatory factor and danger signals, in addition with adipocytokine and adipose tissue genetics.


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